Impacts & Biomarkers Flashcards

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1
Q

What are the three main parts of the brain and their primary functions?

A

Prefrontal Cortex: Thinking, planning, inhibiting actions; goes offline during threats.
Limbic Brain: Emotions, relationships, monitoring danger; develops in early childhood.
Brainstem: Basic functions like breathing, sleep, and threat response; highly responsive to threat throughout life.

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2
Q

What is the autonomic nervous system (ANS), and what are its two branches?

A

Sympathetic NS: Mobilizes the body for action (e.g., fight or flight).
Parasympathetic NS: Calms the body, returning it to regular function.

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3
Q

What is Polyvagal Theory, and who proposed it?

A

Proposed by Stephen Porges, the theory explains how the vagus nerve regulates safety and danger responses, shaping human connection and survival strategies.

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4
Q

What are the three stages of autonomic response in Polyvagal Theory?

A

Ventral Vagal (PNS): Social engagement and safety.
Sympathetic (NS): Fight or flight response to danger.
Dorsal Vagal (PNS): Shutdown response to life-threatening situations.

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5
Q

What are the three main trauma responses outlined by Judith Herman?

A

Hyperarousal: Ongoing expectation of danger.
Intrusion: Reliving traumatic events through flashbacks or nightmares.
Dissociation: Numbing or compartmentalizing experiences.

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6
Q

How does trauma affect memory?

A

Trauma disrupts memory organization, often leading to fragmented memories stored in implicit memory systems (e.g., sensations, images) rather than verbal recall.

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7
Q

What is dissociation, and what are its symptoms?

A

Dissociation involves compartmentalizing traumatic experiences. Symptoms include:
Depersonalization: Feeling detached from one’s body.
Derealization: Feeling detached from reality.
Dissociative amnesia: Memory loss for parts of life or events.
Identity confusion/alteration: Changes in self-perception or identity.

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8
Q

What is epigenetics, and how does it relate to trauma?

A

Epigenetics studies changes in gene expression caused by experiences, such as trauma. These changes can be passed down through generations, influencing resilience or vulnerability to stress.

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9
Q

What are the findings of the QUT epigenetic study on PTSD, resilience, and posttraumatic growth (PTG)?

A

PTSD: FKBP5 methylation significant.
Resilience: NR3C1 methylation predicts low resilience.
PTG: NR3C1 and FKBP5 methylation predict PTG, with specific regions linked to heightened or lower PTG.

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10
Q

Why is using methods like epigenetics and EEG important in trauma research?

A

These methods help identify biological markers of trauma, resilience, and growth, offering insights into underlying mechanisms and guiding personalized interventions.

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11
Q

What role does the vagus nerve play in the autonomic nervous system?

A

The vagus nerve acts as a neural brake, regulating physiological states through its two branches:
Ventral Vagus: Promotes connection, safety, and calmness.
Dorsal Vagus: Activates shutdown or dissociation in response to life-threatening danger.

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12
Q

What is ‘neuroception’ according to Polyvagal Theory?

A

Neuroception is the nervous system’s ability to evaluate risk and safety without conscious awareness, responding to cues inside the body, in the environment, and in relationships.

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13
Q

How does trauma impact the autonomic nervous system?

A

Trauma can attune the nervous system to a low reactivity threshold, leading to misreading of safety and danger cues, altered responses, and difficulty regulating physiological states.

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14
Q

What is hyperarousal, and what are its symptoms?

A

Hyperarousal is the heightened state of alertness and readiness for danger, with symptoms like:
Sleeping difficulties
Anxiety
Irritability
Aggression
Increased startle response
Chronic irritability and somatic issues (e.g., heart problems).

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15
Q

How can traumatic memories differ from regular memories?

A

Traumatic memories are often disorganized, fragmented, and stored in implicit memory systems (e.g., body sensations, images), rather than as a coherent verbal narrative.

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16
Q

What are ‘positive’ and ‘negative’ symptoms of dissociation?

A

Positive symptoms: Traumatic re-experiencing, such as sensory distortions, pain, or panic.
Negative symptoms: Loss of affect, sensation, or motor functioning, and detachment from the environment.

17
Q

What are some long-term effects of trauma on the brain and body?

A

Chronic dysregulation of the nervous system
Difficulty distinguishing between safety and danger cues
Disconnection between emotions and memories
Physical issues like cardiovascular problems or chronic pain.

18
Q

What are the five key ways dissociation can manifest?

A

Depersonalization: Feeling detached from the body.
Derealization: Feeling like the world is unreal.
Dissociative amnesia: Gaps in memory.
Identity confusion: Confusion about one’s identity.
Identity alteration: Shifts in behavior or personality.

19
Q

How does trauma disrupt connectedness, according to Porges and Dana?

A

Trauma replaces patterns of connection with patterns of protection, causing chronic disruptions in emotional and social engagement.

20
Q

What is the significance of the HPA axis in trauma research?

A

The HPA axis regulates stress responses (fight or flight). Altered gene expression patterns in HPA-axis genes (e.g., FKBP5, NR3C1) have been linked to PTSD, resilience, and posttraumatic growth.