immunotherapy drugs for cancer

Question 1

drugs that target T reg cells, try to eliminate them

Answer 1

Cyclophosphamide, Ontak, Ipilimumab

Question 2

function of cyclophosphamide

Answer 2

enhances T cell immunotherapy of tumors through elimination of tumor-induced suppressor T cells (CD4+ Tregs); also enhances DTH responses in skin tests

Question 3

what does Ontak target?

Answer 3

CD25 expressed by Treg

Question 4

what is the generic name for Ontak?

Answer 4

denileukin diftitox

Question 5

what is Ontak composed of?

Answer 5

a fusion of IL-2 and diphtheria toxin

Question 6

what does Ipilimumab target?

Answer 6

CTLA-4 expressed by Treg

Question 7

what is Ipilimumab FDA-approved to treat?

Answer 7

melanoma

Question 8

checkpoint inhibitors

Answer 8

Ipilimumab, Nivolumab, pembrolizumab

Question 9

checkpoint inhibitors are composed of what kind of molecules?

Answer 9

chimeric or humanized monoclonal antibodies

Question 10

target of Ipilimumab?

Answer 10

CTLA-4

Question 11

target of Nivolumab, pembrolizumab?

Answer 11

PD-1

Question 12

what disease are checkpoint inhibitors used to treat?

Answer 12

melanoma

Question 13

monoclonal antibody drug that targets HER2/neu

Answer 13

Herceptin (trastuzumab)

Question 14

monoclonal antibody drug that targets CD20

Answer 14

Rituxan (rituximab)

Question 15

monoclonal antibody that targets VEGF

Answer 15

Avastin (bevacizumab)

Question 16

monoclonal antibody drug that targets EGFR

Answer 16

Erbitux (cetuximab)