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Immunology > immunotherapy > Flashcards

immunotherapy Flashcards

1
Q

Nivolumab

A

PD1 inhibitor on T cells

checkpoint blockade in cancer therapy

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2
Q

Atezolizumab

A

PDL1 inhibitor on cancer cells

checkpoint blockade in cancer therapy

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3
Q

Ipilimumab

A

CTLA4 inhibitor on T cells

checkpoint blockade in cancer therapy

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4
Q

Trustuzumab

A

Block Her2 on tumor cells

blockage of tumor receptor promoting growth

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5
Q

Catumaxumab

A

CD3 and EpCAM inhibitor in cancer therapy

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6
Q

Alemtuzumab

A

CD52 inhibitor on lymphocytes

used in transplantation, multiple sclerosis, leukemia, lymphoma

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7
Q

Bazlotoxumab

A

Anti C.difficle toxin

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8
Q

Natalizumab

A

Integrin alpha4 inhibitor

used in Crohn’s disease, multiple sclerosis

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9
Q

Ustekinumab

A

Inhibits P40 subunit participates in the formation of IL12 and IL23
used in chronic inflammatory disorders

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10
Q

Methotrexate

A

Inhibits intracellular enzymes in RA

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11
Q

Adalimumab

A

Inhibits TNFalpha used in RA

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12
Q

Tocilizumab

A

Inhibits IL6 used in RA

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13
Q

Rituximab

A

Inhibits CD20 on B cells used in RA

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14
Q

Denosumab

A

Inhibits RANK-L used in RA

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15
Q

Proleukin

A

Recombinant human IL2 in immunodeficiencies

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16
Q

Peglentron

A

Recombinant human IFN alpha in immunodeficiencies

17
Q

Flebogamma / Pivigen

A

IVIG

18
Q

Provenge

A

Leukopheresis for prostate cancer

19
Q

Imlygic

A

Genetically engineered HSV to produce GM-CSF and attack tumorous melanocytes (stage 3-4 melanoma)

20
Q

Omalizumab

A

IgE inhibitor used in sustained asthma treatment

21
Q

Mepolizumab

A

Inhibition of IL5 used in asthma treatment

22
Q

Reslizumab

A

Inhibition of IL5 used in asthma treatment

23
Q

Benralizumab

A

Inhibition of IL5R alpha used in asthma treatment

24
Q

Abatacept

A

CTLA4 + IgG1 Fc region inhibition of T cell activation

25
Q

Cetuximab

A

inhibition of EGFR used in antitumor therapy

26
Q

Imiquimad

A

TLR7 agonist turns chronic inflammation to acute inflammation used in antitumor treatment

Immunology (1 decks)

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