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4 - Y5 Charlie Rooke Pathology > Immunotherapies > Flashcards

Immunotherapies Flashcards

1
Q

A letter AND a number

Psoriasis

A. Inhibit RANK ligand
B. Inhibit IL12/23 or TNF alpha
C. Inhibit TNF alpha
D. Inhibit IL6 or TNF alpha

  1. Ustekinumab or etanercept
  2. Infliximab
  3. Denosumab
  4. Adalimumab or tocilizumab
A

Inhibit IL12/23 or TNF alpha

Ustekinumab or etanercept

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2
Q

A letter AND a number

Rheumatoid arthritis

A. Inhibit RANK ligand
B. Inhibit IL12/23 or TNF alpha
C. Inhibit TNF alpha
D. Inhibit IL6 or TNF alpha

  1. Ustekinumab or etanercept
  2. Infliximab
  3. Denosumab
  4. Adalimumab or tocilizumab
A

D. Inhibit IL6 or TNF alpha

  1. Adalimumab or tocilizumab
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3
Q

A letter AND a number

Osteoporosis

A. Inhibit RANK ligand
B. Inhibit IL12/23 or TNF alpha
C. Inhibit TNF alpha
D. Inhibit IL6 or TNF alpha

  1. Ustekinumab or etanercept
  2. Infliximab
  3. Denosumab
  4. Adalimumab or tocilizumab
A

A. Inhibit RANK ligand

3. Denosumab

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4
Q

A letter AND a number

Crohn’s disease

A. Inhibit RANK ligand
B. Inhibit IL12/23 or TNF alpha
C. Inhibit TNF alpha
D. Inhibit IL6 or TNF alpha

  1. Ustekinumab or etanercept
  2. Infliximab
  3. Denosumab
  4. Adalimumab or tocilizumab
A

C. Inhibit TNF alpha

2. Infliximab

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5
Q

Basiliximab (Anti-IL2 receptor)

A. Inhibits T cell migration but may only be used in highly active remitting/relapsing MS

B. Inhibits T cell activation and is effective in rheumatoid arthritis

C. Depletes B cells and is effective in treatment of B cell lymphomas and rheumatoid arthritis

D. Inhibits function of lymphoid and myeloid cells and used in management of rheumatoid arthritis

E. Antibody specific for CD25 which inhibits T cell activation and is used to prevent rejection

A

E. Antibody specific for CD25 which inhibits T cell activation and is used to prevent rejection

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6
Q

Abatacept (CTLA4-Ig fusion protein)

A. Inhibits T cell migration but may only be used in highly active remitting/relapsing MS

B. Inhibits T cell activation and is effective in rheumatoid arthritis

C. Depletes B cells and is effective in treatment of B cell lymphomas and rheumatoid arthritis

D. Inhibits function of lymphoid and myeloid cells and used in management of rheumatoid arthritis

E. Antibody specific for CD25 which inhibits T cell activation and is used to prevent rejection

A

B. Inhibits T cell activation and is effective in rheumatoid arthritis

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7
Q

Rituximab (Anti-CD20)

A. Inhibits T cell migration but may only be used in highly active remitting/relapsing MS

B. Inhibits T cell activation and is effective in rheumatoid arthritis

C. Depletes B cells and is effective in treatment of B cell lymphomas and rheumatoid arthritis

D. Inhibits function of lymphoid and myeloid cells and used in management of rheumatoid arthritis

E. Antibody specific for CD25 which inhibits T cell activation and is used to prevent rejection

A

C. Depletes B cells and is effective in treatment of B cell lymphomas and rheumatoid arthritis

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8
Q

Natalizumab (Anti- a4 integrin)

A. Inhibits T cell migration but may only be used in highly active remitting/relapsing MS

B. Inhibits T cell activation and is effective in rheumatoid arthritis

C. Depletes B cells and is effective in treatment of B cell lymphomas and rheumatoid arthritis

D. Inhibits function of lymphoid and myeloid cells and used in management of rheumatoid arthritis

E. Antibody specific for CD25 which inhibits T cell activation and is used to prevent rejection

A

A. Inhibits T cell migration but may only be used in highly active remitting/relapsing MS

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9
Q

Tocilizumab (Anti-IL6 receptor)

A. Inhibits T cell migration but may only be used in highly active remitting/relapsing MS

B. Inhibits T cell activation and is effective in rheumatoid arthritis

C. Depletes B cells and is effective in treatment of B cell lymphomas and rheumatoid arthritis

D. Inhibits function of lymphoid and myeloid cells and used in management of rheumatoid arthritis

E. Antibody specific for CD25 which inhibits T cell activation and is used to prevent rejection

A

D. Inhibits function of lymphoid and myeloid cells and used in management of rheumatoid arthritis

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10
Q

Cyclophosphamide

A. Osteoporosis
B. Infertility
C. Progressive multifocal leukoencephalopathy
D. Neutropenia particularly if TPMT low
E. Hypertension
A

B. Infertility

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11
Q

Prednisolone

A. Osteoporosis
B. Infertility
C. Progressive multifocal leukoencephalopathy
D. Neutropenia particularly if TPMT low
E. Hypertension
A

A. Osteoporosis

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12
Q

Azathioprine

A. Osteoporosis
B. Infertility
C. Progressive multifocal leukoencephalopathy
D. Neutropenia particularly if TPMT low
E. Hypertension
A

D. Neutropenia particularly if TPMT low

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13
Q

Cyclosporin

A. Osteoporosis
B. Infertility
C. Progressive multifocal leukoencephalopathy
D. Neutropenia particularly if TPMT low
E. Hypertension
A

E. Hypertension

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14
Q

Mycophenolate mofetil

A. Osteoporosis
B. Infertility
C. Progressive multifocal leukoencephalopathy
D. Neutropenia particularly if TPMT low
E. Hypertension
A

C. Progressive multifocal leukoencephalopathy

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15
Q

IFN alpha

A. Post-transplant lymphoproliferative disorder
B. Part of treatment for Hepatitis C C. X linked hyper IgM syndrome D. X linked SCID E. Chronic granulomatous disease
F. Immunosuppressed seronegative individual after chicken pox exposure

A

B. Part of treatment for Hepatitis C

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16
Q

Bone marrow transplantation

A. Post-transplant lymphoproliferative disorder
B. Part of treatment for Hepatitis C C. X linked hyper IgM syndrome D. X linked SCID E. Chronic granulomatous disease
F. Immunosuppressed seronegative individual after chicken pox exposure

A

D. X linked SCID

17
Q

IFN gamma

A. Post-transplant lymphoproliferative disorder
B. Part of treatment for Hepatitis C C. X linked hyper IgM syndrome D. X linked SCID E. Chronic granulomatous disease
F. Immunosuppressed seronegative individual after chicken pox exposure

A

E. Chronic granulomatous disease

18
Q

EBV-specific CD8 T cells

A. Post-transplant lymphoproliferative disorder
B. Part of treatment for Hepatitis C C. X linked hyper IgM syndrome D. X linked SCID E. Chronic granulomatous disease
F. Immunosuppressed seronegative individual after chicken pox exposure

A

. Post-transplant lymphoproliferative disorder

19
Q

Human normal immunoglobulin

A. Post-transplant lymphoproliferative disorder
B. Part of treatment for Hepatitis C C. X linked hyper IgM syndrome D. X linked SCID E. Chronic granulomatous disease
F. Immunosuppressed seronegative individual after chicken pox exposure

A

C. X linked hyper IgM syndrome

20
Q

Varicella zoster immunoglobulin

A. Post-transplant lymphoproliferative disorder
B. Part of treatment for Hepatitis C C. X linked hyper IgM syndrome D. X linked SCID E. Chronic granulomatous disease
F. Immunosuppressed seronegative individual after chicken pox exposure

A

F. Immunosuppressed seronegative individual after chicken pox exposure

4 - Y5 Charlie Rooke Pathology (3 decks)

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