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USMLE First AID > Immunosupressive > Flashcards

Immunosupressive Flashcards

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USMLE® Step 1 flashcards
0
Q

Thronbovytopenia

A

Thrombopoetin and oprelvekin (IL11)

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1
Q

Anemia (especially in renal failure)

A

EPO

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2
Q

Recovery of bone marrow

A

Filgastrim sagramostim

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3
Q

RCC metastatic melanoma

A

Aldesleukin (IL2)

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4
Q

Multiple sclerosis

A

IFN B

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5
Q 
Chronic hepatitis B and a
Kaposi sarcoma
Hairy cell leukemia 
condylomata acuminatum 
Renal cell carcinoma
Malignant melanoma
A

IFN a

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6
Q

CGD

A

IFN gamma

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7
Q

CLL targeting CD52

A

aLYMTuzumab for chronic LYMphocytic leukemia

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8
Q

Colorectal cancer
Renal cell carcinoma
Targeting VEGF

A

Bevacizumab

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9
Q

Stage IV colorectal cancer
Head and neck cancer
Targeting EGFR

A

Cetuximab

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10
Q

B cell NHL
RA with mtx
ITP
Targeting CD20

A

Rituximab

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11
Q

Breast cancer and gastric cancer targeting HER2/neu

A

Trastuzumab

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12
Q

IBD, RA, ankylosing spondylitis, psoriasis targeting TNF-a

A

Infliximab, adalimumab

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13
Q

Multiple sclerosis, Crohn disease a4-integrin target

A

Natalizumab

Risk of PML in patients with JC Virus

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14
Q

Anti-platelet agent for prevention of ischemic complications in patients undergoing percutaeneous coronary intervention targeting Glycoprotein IIb/IIIa

A

Abciximab

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15
Q

Osteoporosis; inhibitis osteoclast maturation (mimics osteoprotegrin) targeting RANKL

A

Denosumab

16
Q

Antidote for digoxin toxicity

A

Digoxin immune Fab

17
Q

Allergic asthma; prevents IgE binding to FceRI

A

Omalizumab

18
Q

RSV prophylaxis for high-risk infants to target the RSV F protein

A

PaliVIzumab - VIrus

19
Q

Calcineurin inhibitor which binds to cyclophylin. Thus blocking T cell activation by preventing IL-2 transcription. Gingival hyperplasia and nephrotoxic.

A

Cyclosporine

20
Q

Calcineurin inhibitor which binds to FK506. Thus blocking T cell activation by preventing IL-2 transcription. No ginvival hyperplasia or hirsutism.

A

Tacrolimus

21
Q

mTOR inhibitor; bind FKBP. Blocks T cell activation and B cell differentiation by preventing IL-2 signal transdcution.

A

Kidney SIRvives. Synergystic with cyclosporine.

Sirolimus (Rapamycin)

22
Q

Monoclonal antibody; blocks IL2R

A

Basiliximab

23
Q

Antimetabolite precursor of 6-MP. Injinits lymphocyte proliferation by blocking nucleotide synthesis. For Transplant rejection, RA, Crohn disease, GN

A

Azathiprine

24
Q

Inhibit NF-kB. Suppress both B and T cell function by decreasing transcription of many cytokines

A

Glucocorticoids.

USMLE First AID (2 decks)

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