Immunosupressants Flashcards

1
Q

Inhibit enzyme in purine synthesis through inhibition of inosine monophosphate dehydrogenase

A

Mycophenalte motefil (MMF)

Mycophenolate sodium (MPS)

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2
Q

Mycophenolate motefil

A

Anti-proliferative

Inhibits purine synthesis: inhibits inosine monophosphate dehydrogenase

More selective and effective vs azathioprine

Blocks T-cell and B-cell proliferation

Prevents smooth muscle proliferation - also beneficial in preventing chronic rejection

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3
Q

Non-specific blockade of nucleic acid synthesis

A

Azathioprine

Non-specific

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4
Q

Azathioprine

A

Anti-proliferative

Blocks nucleic acid synthesis

Non-specific: affects all rapidly dividing cells
i.e. T cells undergoing clonal expansion

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5
Q

Inhibit T cell activation by inhibiting IL-2 gene transcription

A

Calcineurin inhibitors

Ciclosporin
Tacrolimus

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6
Q

Ciclosporin and Tacrolimus

A

Both drugs are calcineurin inhibitors and fungal products

Inhibit T cell activation by blocking IL-2 gene transcription

–> inhibit cytotoxic T cell generation

Both nephrotoxic - requiring blood level monitoring as nephrotoxicity is level-dependent

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7
Q

Macrolide antibiotic that blocks mTOR

A

Rapamycin (sirolimus)

Blocks mTOR

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8
Q

Rapamycin

A

Macrolide antibiotic

Blocks protein-designated mammalian target of rapamycin (mTOR)

–> inhibition reduces cytokine-dependent cellular proliferation at G1 to S phase of cell division cycle

–> thereby blocking T-cell activation

Non-nephrotoxic
Impairs wound healing

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9
Q

Anti-IL-2R

A

Basiliximab

Daclizumab

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