Immunosuppressive drugs Flashcards by M J | Brainscape

Q

Glucocorticoids

A

regulate gene transcription

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Q

Muromonab (CD3)

A

mouse monoclonal antibody

blocks antigen recognition via T-cell receptor (CD3) binding

cytokine release syndrome (flu like to shock) d/t receptor cross linking

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Q

Cyclosporine

A

calcineurin inhibitor

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Q

Tacrolimus

A

calcineurin inhibitor

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Q

Mycophenolate mofetil

A

IMP dehydrogenase inhibitor – prevents guanine nucleotide synthesis

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Q

Daclizumab, Basiliximab

A

IL-2 receptor antibody – blocks activation

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Q

Sirolimus

A

interacts with FK binding protein and inhibits mTOR – protein kinase involved in cell-cycle progression (G1 to S)

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