Immunosuppressive Agents Flashcards
1
Q
Types of induction antibodies
A
A. Lymphocytes depleting
- Targets antigens on surface of recipient immune cells leading to removal
1. Rabbit ATG (thymoglobulin) (polyclonal)
2. Alemtuzumab (monoclonal)
3. OKT3
B. Non-lymphocytes depleting
- Blocks receptors on surface of immune cells, deactivating the cells
1. Simulect (Basiliximab) - chimeric anti-CD25 Ab
2. Zenapax (Daclizumab) - humanised anti-CD25 Ab
2
Q
Maintenance Immunosuppressants
A
