immunosuppression

Question 1

omalimuzab

Answer 1

mAb against IgE, prevents mast cell degrnaulation. Used to treat dermatographic utricaria and allergic asthma

Question 2

sodium crymoglycate

Answer 2

inhibits and inward chloride current therefore prevents Ca2+ influx as the Em isn’t balanced. This prevents mast cell degranulation. Used for mastocytosis

Question 3

salbutamol

Answer 3

short acting b2 adrenoreceptor antagonist (asthma treatment)

Question 4

salmetarol

Answer 4

long acting b2 adrenoreceptor antagonist (asthma treatment)

Question 5

theophylline

Answer 5

PDE inhibitor so keeps cAMP levels high. Used prophylactically in the treatment of asthma

Question 6

loratadine

Answer 6

3rd generation anti histamine

Question 7

proglumide

Answer 7

blocks CCK2 receptor. Usually stimulation of this receptor causes release of histamine from ECL cells

Question 8

ranitidine

Answer 8

H2 receptor antagonist used to treat peptic ulcers

Question 9

omeprazole

Answer 9

proton pump inhibitor used to treat peptic ulcers

Question 10

arthrotec

Answer 10

combination drug: NSAID and misoprostol - used in chronic treatment of rheumatoid arthritis to prevent peptic ulcer formation (misoprostol ensures histamine still released despite NSAID = still get mucin, bicarbonate release etc.)

Question 11

icatibant

Answer 11

bradykinin B2 receptor antagonist used to treat hereditary angioedema

Question 12

zafirlukast

Answer 12

CysLT1 receptor antagonist (used to treat asthma)

Question 13

zileuton

Answer 13

5-LO inhibitor, used in asthma treatment

Question 14

ibuprofen

Answer 14

non selective COX inhibitor

Question 15

etoricoxib

Answer 15

COX-2 selective inhibitor

Question 16

naproxcinod

Answer 16

NSAID and NO donor (NO ensure vasodilation to damaged mucosa?)

Question 17

aspirin

Answer 17

irreversible NSAID - lowers platelet aggregation

Question 18

paracetamol

Answer 18

COX inhibitor. analgesic/anti-pyretic but not very anti inflammatory

Question 19

odansetron

Answer 19

5HT3 receptor antagonist used to treat vomiting

Question 20

sumatriptan

Answer 20

5-HT1B/D/F agonist used to treat migraine

Question 21

dexamethasone

Answer 21

anti inflammatory corticosteroid

Question 22

methotrexate

Answer 22

DHFR inhibitor used as a disease modifying anti-rheumatic drug (DMARD) in rheumatoid arthritis

Question 23

penicillamine

Answer 23

a DMARD - suppresses collaged and IL-1 synthesis

Question 24

etanercept

Answer 24

fusion protein of TNFa receptor and IgG` - used in rheumatoid arthritis to mop up TNFa

Question 25

adalimumab

Answer 25

anti-TNFa mAb

Question 26

anakinra

Answer 26

recombinant IL-1 receptor antagonist

Question 27

ciclosporin A

Answer 27

binds to CpN and inhibits IL-2 transcription

Question 28

tacrolimus

Answer 28

binds to FKBP and inhibits IL-2 transcription

Question 29

basiliximab

Answer 29

mAb against CD25 alpha unit of IL-2 receptor

Question 30

azathioprine

Answer 30

inhibits DNA synthesis in cells without a nucleotide savage pathway (includes B and T cells)