immunosuppression Flashcards
omalimuzab
mAb against IgE, prevents mast cell degrnaulation. Used to treat dermatographic utricaria and allergic asthma
sodium crymoglycate
inhibits and inward chloride current therefore prevents Ca2+ influx as the Em isn’t balanced. This prevents mast cell degranulation. Used for mastocytosis
salbutamol
short acting b2 adrenoreceptor antagonist (asthma treatment)
salmetarol
long acting b2 adrenoreceptor antagonist (asthma treatment)
theophylline
PDE inhibitor so keeps cAMP levels high. Used prophylactically in the treatment of asthma
loratadine
3rd generation anti histamine
proglumide
blocks CCK2 receptor. Usually stimulation of this receptor causes release of histamine from ECL cells
ranitidine
H2 receptor antagonist used to treat peptic ulcers
omeprazole
proton pump inhibitor used to treat peptic ulcers
arthrotec
combination drug: NSAID and misoprostol - used in chronic treatment of rheumatoid arthritis to prevent peptic ulcer formation (misoprostol ensures histamine still released despite NSAID = still get mucin, bicarbonate release etc.)
icatibant
bradykinin B2 receptor antagonist used to treat hereditary angioedema
zafirlukast
CysLT1 receptor antagonist (used to treat asthma)
zileuton
5-LO inhibitor, used in asthma treatment
ibuprofen
non selective COX inhibitor
etoricoxib
COX-2 selective inhibitor
naproxcinod
NSAID and NO donor (NO ensure vasodilation to damaged mucosa?)
aspirin
irreversible NSAID - lowers platelet aggregation
paracetamol
COX inhibitor. analgesic/anti-pyretic but not very anti inflammatory
odansetron
5HT3 receptor antagonist used to treat vomiting
sumatriptan
5-HT1B/D/F agonist used to treat migraine
dexamethasone
anti inflammatory corticosteroid
methotrexate
DHFR inhibitor used as a disease modifying anti-rheumatic drug (DMARD) in rheumatoid arthritis
penicillamine
a DMARD - suppresses collaged and IL-1 synthesis
etanercept
fusion protein of TNFa receptor and IgG` - used in rheumatoid arthritis to mop up TNFa
