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immunology > Immunosuppressants > Flashcards

Immunosuppressants Flashcards

1
Q

Ciclosporine MA

A

Inhibits calcineurin, by binding to ciclophilin. Inhibiting IL-2 transcription, activation of T cells.

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2
Q

Ciclosporine RAMs

A 
Hypertension 
Hyperlipidemia
Neurotoxicity
Nephrotoxicity 
Hirsutism
Gingival hyperplasia
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3
Q

Tacrolimus MA

A

Inhibits Calcineurin by binding to FKBP.

Inhibits transcription of I-L2.

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4
Q

Tacrolimus RAMs

A 
Neurotoxicity +++
Nephrotoxicity
Hyperlipidemia 
Hypertension
Risk of DIABETES
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5
Q

Sirolimus MA

A

Inhibits mTOR by binding to FKBP.

Inhibits t cell activation and b cell differentiation, preventing IL-2 response

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6
Q

Sirolimus RAMS

A

Pancytopenia
Insulin resistance
Hyperlipidemia

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7
Q

Synergistic to cyclosporine

A

Sirolimus

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8
Q

Basiliximab MA

A

Monoclonal antibody, blocks IL-2 receptors

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9
Q

Basiliximab MA

A

Edema
Hypertension
Tremor

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10
Q

Azathioprine

A

Antimetabolite precursor of 6-MP, inhibits PRPP amidotransferase, inhibiting lymphocyte production by blocking nucleotide synthesis.

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11
Q

Azathioprine uses in:

A

Rheumatoid disease
Crohn Disease
Glomerulonephritis
Other autoimmune

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12
Q

Azathioprine RAMs

A

Pancitopenia

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13
Q

Increases toxicity by allopurinol

A

Azathioprine

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14
Q

Mycophenolate

A

Inhibits IMP dehydrogenase, preventing synthesis of guanosine nucleotides of b and t cells

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15
Q

Mycophenolate RAMs

A 
GI upset 
Pancitopenia 
Hypertension 
Hyperglicemia 
Less nephrotoxic and neurotoxic
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16
Q

Associated with invasive CMV infection

A

Mycophenolate

17
Q

Corticoesteroids MA

A

Inhibit NFkB, supress both t and b cell function, decreases transcription of cytokines. Induce t cell apoptosis

18
Q

COrticoesteroids use

A 
Adrenal insufficiency
CLL
Non-Hodgkin lymphoma 
Asthma
Others
19
Q

corticoesteroid RAMS

A 
Adrenocortical atrophy
Amenorrhea
Peptic ulcers
Cataracts
Cushing syndrome 
Osteoporosis 
Hyperglycemia 
Diabetes
Pyschosis
Avascular necrosis
20
Q

Demargination of WBC-leukocytosis

A

Corticoesteroids

immunology (5 decks)

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