Immunosuppressant drugs

Question 1

What 4 drugs work on the induction phase of the immune response?

Answer 1

Cyclosporine, Tacromilus, glucocorticoids, monoclonal antibodies

Question 2

What 6 drugs work on the effector phase of immune response?

Answer 2

sirolimus, mycophenolate mofetil, Azathioprine, cyclophosphamide, poly- and mono-clonal antibodies

Question 3

Name 2 inhibitors of IL-2 production

Answer 3

Cyclosporine, Tacrolimus

Question 4

Name an inhibitor of cytokine gene expression

Answer 4

glucocorticoids

Question 5

name an inhibitor of IL-2 action (NOT gene)

Answer 5

Sirolimus (think like tacrolimus)

Question 6

name 2 inhibitors of purine synthesis

Answer 6

Mycophenolate mofetil, Azathioprine

Question 7

name an alkylating agent (cytotoxic drug)

Answer 7

cyclophosphamide

Question 8

Describe how to prevent acute rejection (drug tx)

Answer 8

• high dose glucocorticoids, purine synthesis inhibitors, immunosuppressive antibodies
• start 1-2 weeks prior to transplant

Question 9

prevention of chronic rejection

Answer 9

Triple therapy consisting of low dose:

• Calcenurin inhibitor (cyclosporine, tacrolimus)
• Inhibitor of purine synthesis: Mycophenolate, Azthioprine)
• glucocorticoid

Question 10

DMARDs?

Answer 10

Disease Modifying Antirheumatic Drugs

Question 11

list some DMARDs for RA therapy

Answer 11

• methotrexate
• sulfasalazine
• leflunomide
• anti-TNFa therapies
• anti-IL therapies

Question 12

List some anti-TNF based therapeutics

Answer 12

• entancercept
• infliximab
• adalimumab
• certolizumab
• golimumab

(-mabs)

Question 13

Which drug is the only soluble TNFa antagonist?

Answer 13

Etanercept

Question 14

List 3 anti-IL based drugs

Answer 14

• anakinra
• Canakinumab
• Tocilizumab

(-Umabs)