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PHOT Boards 2023 > Immunophenotype Markers > Flashcards

Immunophenotype Markers Flashcards

1
Q

HLA-DR

A
  • Marker of immaturity that is very common in leukemias, except:
  • Almost absent in APML FAB M3 (10%)
  • Less common in AMKL FAB M7 (30%)
  • Not common in T-ALL
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2
Q

TDT

A
  • Marker of lymphoid immaturity
    (B- and T-ALL)
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3
Q

CD10

A
  • B-ALL marker, aka. common ALL antigen (CALLA)
  • Not expressed in KMT2A-rearranged B-ALL
  • Also positive in 1/3 of T-ALL
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4
Q

CD15

A
  • Classical Hodgkin lymphoma
  • Typically, CD15 and CD30 positive, CD45 negative, down-regulated B cell markers
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5
Q

CD19

A
  • Pan B cell marker
  • Often aberrantly expressed in AML with a t(8;21) translocation
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6
Q

CD20

A

B cell marker

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7
Q

CD22

A
  • B-ALL marker
  • Typically, only found in mature B-cells in non-ALL settings
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8
Q

CD30

A
  • Classical Hodgkin lymphoma
  • Typically, CD15 and CD30 positive, CD45 negative, down-regulated B cell markers
  • PMBL
  • ALCL
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9
Q

CD45

A
  • NLPHL (CD45 positive, CD15 negative, CD30 negative)
  • Retains some other B cell markers
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10
Q

CD79

A

Pan B cell marker

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11
Q

CD3

A

T cell marker

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12
Q

CD4

A
  • T helper cell marker
  • Binds to MHC class II expressed on antigen-presenting cells
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13
Q

CD43

A

Deficient or abnormal glycosylated in T cells in WAS

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14
Q

CD5

A
  • T cell marker
  • Expressed on a small subset of B cells (B1a cells)
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15
Q

CD7

A

T cell marker

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16
Q

CD8

A
  • Cytotoxic T cell marker
  • Binds to MHC class I expressed on all healthy cells as part of self-surveillance
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17
Q

CD13

A
  • Pan-myeloid marker, positive in AML
  • Aberrantly expressed in ETV6-RUNX1 and BCR-ABL1 ALL
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18
Q

CD14

A
  • Monocytic marker
19
Q

CD163

A
  • Rosai-Dorfman disease and Juvenille xanthogranuloma
  • Monocyte and macrophage marker
  • Identifies emperipolesis
20
Q

CD1a

A

LCH Marker

21
Q

CD207

A

LCH Marker

22
Q

CD33

A
  • Pan-myeloid marker, positive in AML
  • Aberrantly expressed in ETV6-RUNX1 and BCR-ABL1 ALL
23
Q

MPO

A
  • Pan-myeloid marker, positive in AML
  • Not expressed in AMKL FAB M7
24
Q

CD11b

A
  • Loss of CD11a/b in LAD type 1
  • Forms the macrophage-1 antigen receptor, Mac-1, when bound to CD18
25
Q

CD18

A
  • Loss of CD18 in LAD type 1 due to mutations in ITGB2 (ß2-integrins)
  • ß2-integrins are an essential component of CD18
  • Forms the macrophage-1 antigen receptor, Mac-1, when bound to CD11b
26
Q

CD235A

A
  • Erythroid marker (aka. glycophorin A), positive in AML FAB M6
27
Q

CD55

A
  • Absent in PNH, mutations in PIGA lead to a deficiency of CD55/59
  • Allows complement (C3) to activate the alternative pathway and mediate hemolysis
  • Patients also at risk for thrombosis
28
Q

CD59

A
  • Absent in PNH, mutations in PIGA lead to a deficiency of CD55/59
  • Allows complement (C3) to activate the alternative pathway and mediate hemolysis
  • Patients also at risk for thrombosis
29
Q

CD41a

A
  • Platelet marker, positive in AMKL FAB M7
30
Q

CD42

A
  • Platelet marker, positive in AMKL FAB M7
31
Q

CD61

A
  • Platelet marker, positive in AMKL FAB M7
32
Q

GP1B

A
  • Absent in Bernard-Soulier syndrome
  • Binds von Willebrand factor
  • Pathologically higher affinity of GP1b in von Willebrands Disease type 2B (platelet type)
33
Q

GP2b/3a

A
  • Deficient in **Glanzman’s **thrombasthenia
  • Platelet marker that binds to fibri
34
Q

CD107a

A
  • Degranulation marker to measure natural killer cell function
  • Useful in the diagnosis of HLH
35
Q

CD56

A
  • Neuroblastoma and natural killer cell marker
  • Neural cell adhesion molecule (NCAM)
36
Q

CD99

A
  • Ewing sarcoma and PNET
37
Q

Cytokeratin

A
  • Synovial carcinoma (as well as some other sarcomas)
38
Q

Desmin

A

Rhabdomyosarcoma

39
Q

Muscle Specific Actin

A

Rhabdomyosarcoma

40
Q

MyoD

A

Rhabdomyosarcoma

41
Q

Myogenin

A
  • RMS, diffusely positive in ARMS, patchy positive in ERMS
42
Q

NSE

A
  • Neuroblastoma and sometimes Ewing Sarcoma
43
Q

Synaptophysin

A
  • Neuroblastoma and PNET
44
Q

Vimentin

A
  • Ewing sarcoma, PNET, and synovial sarcoma marker

PHOT Boards 2023 (6 decks)

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