Immunopharmacology Flashcards
Cyclosporine MOA.
The drug binds to cyclophilin protein > dec calcineurin (cytoplasmic phosphatase) >dec. activation of T- cell transcription factors dec. IL -2, IL-3, and interferon-y
Tacrolimus MOA.
The drug binds to FK binding protein > dec calcineurin (cytoplasmic phosphatase) >dec. activation of T- cell transcription factors dec. IL -2, IL-3, and interferon-y
Indication cyclosporine?
DOC for organ or tissue tranplantation
Indication tacrolimus?
used as an alternate to cyclosporine in renal and liver transplants
S/E of tacrolimus and cyclosporine?
nephrotoxicity (both), gingival overgrowth (cyclosporine)
Mycophenolate indication.
is an inhibitor of de novo synthesis of purines, has adjunctive immunosuppressant actions, permitting dose reductions of cyclosporine to limit toxicity?
MOA azathioprine. Indications?
converted to 6-MP
immunosuppressant
Another name for anti-D immunoglobulin?
RhoGAM
MOA anti-D immunoglobulin?
human IgG antibodies to red cell D antigen (rhesus ag)
Indication for anti-D immunoglobulin.
administer to Rh-negative mother within 72 hours of Rh-positive delivery to prevent hemolytic disease of newborn in subsequent pregnancy
In addition to RA infliximab and adalimumab can treat what condition?
Crohns disease
Muromonab indication.
kidney transplant: blocks allograft rejection
Palivizumab indication? MOA?
RSV: blocks RSV protein
Rituximab Indication? MOA?
Non-Hodgkin lymphoma: binds to surface protein
Basiliximab indication? MOA?
prevent organ rejection: IL -2 receptor antagonist
