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Path B10 > Immunopathology Lec1 > Flashcards

Immunopathology Lec1 Flashcards

1
Q

Redness

A

Rubor

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2
Q

Tumor

A

Swelling

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3
Q

Pain

A

Dolor

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4
Q

Loss of function

A

Functio laesa

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5
Q

Macrophages kill and eat but don’t digest themselves the ___________.

A

Present

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6
Q

Causes vasodilation and increases vascular permeability

A

Histamine

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7
Q

Causes vasodilation and increased vascular permeability

A

Serotonin

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8
Q

Pain and vasodilation (increases leakyness)

A

Bradykinin

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9
Q

What are the effects of bradykinin?

A

Vasodilation
PAIN!
Increased vascular permeability
Bronchoconstruction

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10
Q

C5a and IL8 are __________________ attractants

A

Neutrophil

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11
Q

What causes degranulation of mast cells?

A

Anaphylatoxins (C3a and C5a)

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12
Q

THis causes pain and fever.

A

PGE2

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13
Q

What neutralizes Thromboxane A2?

A

Aspirin

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14
Q

Lipoxygenase pathway in Lungs involve what that leads to inflammation and bronchoconstriction in Asthma?

A

Leukotrienes

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15
Q

These don’t have a nucleus therefore they cant regenerate TXA2.

A

Platelets

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16
Q

___________ causes liver to make acute phase reactants.

A

IL-6

17
Q

These cytokines activate endothelial cell adhesion molecules, initiate PGE2 synthesis in anterior hypothalamus, leading to production of fever and pain.

A

IL-1 and TNFalpha

18
Q

This cytokines does PMN chemotaxis

A

IL-8

19
Q

What are 4 outcomes of Acute inflammation:

A

Complete resolution with regeneration
Complete resolution with scarring
Abscess formation
Transition to chronic inflammation

20
Q

Know the difference between conjunctivitis and scleritis…

A

Both cause red eye, if sclera is inflamed it will be painful…. Conjunctivitis itches and isn’t pain.

21
Q 
Important cells for chronic inflammation: 
Macrophages
Histiocytes
Kupffer cells
Osteoclasts
Micoglia
A 
Macrophages: monocytes
HIstiocytes: connective tissues
Kupffer cells: liver
Osteoclasts: bone
Micoglia: brain
22
Q

What play a key role in parasitic infections and IgE-mediated allergic reactions.

A

Eosinophils

23
Q

Eosinophils contain ___________________, which is toxic to parasites.

A

Major basic protein

24
Q

WHat are the 4 types of necrosis?

A

Coagulative
Liquefactive
Caseous
Fat

25
Q

Ischemia is usually ________________ necrosis, but in the brain it is ________________ necrosis.

A

Coagulative

Liquefactive

26
Q

Liquefaction in most of the body is caused by infection from organisms, but not in the ___________.

A

Brain

27
Q

“Cheesy” proteinaceous dead cell mass

A

Caseous necrosis

28
Q

This is death in adipose tissue… small white lesions are formed in subcutaneous tissue because of trauma.

A

Fat necrosis

29
Q

This is critical in fine-tuning the developing retina.

A

Apoptosis

30
Q

Well organized destruction of cells

A

Apoptosis

Path B10 (1 decks)

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