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immunopath > Immunopathology Awkwards > Flashcards

Immunopathology Awkwards Flashcards

1
Q

HLAB4 is a haplotype of this arthritis.

A

Rheumatoid Arthritis

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2
Q

HLA-DRB1

A

Rheumatoid Arthritis.

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3
Q

TH17

A

Neutrophil recruitment – Rheumatoid Arthritis

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4
Q

TH1

A

Interferon Gamma (y) – Rheumatoid Arthritis

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5
Q

RANKL

A

Rheumatoid Arthritis

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6
Q

TNF

A

Rheumatoid Arthritis

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7
Q

Anti-Citrullinated Peptide Antibodies (ACPA)

A

Rheumatoid Arthritis (Specific)

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8
Q

COL2A1 gene

A

Familial Osteoarthritis

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9
Q

WNT signalling, Prostaglandin pathways

A

Osteoarthritis

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10
Q

Caplans Syndrome

A

Rheumatoid arthritis (RA) and pneumoconiosis combination.

Manifests as intrapulmonary nodules, which appear homogenous and well-defined on chest X-Ray

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11
Q

Felty’s Syndrome

A

Combination of heumatoid arthritis, splenomegaly and neutropenia.

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12
Q

ANA

A

Oligoarthritis (Juvenile Idiopathic Arthritis Subtype)

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13
Q

RF+

A

Polyarthritis (Juvenile Idiopathic Arthritis Subtype)
Ddx
10% of Psoriatic Arthritis

Sjogrens (75%)

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14
Q

Stills Disease

A

Systemic Onset JIA

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15
Q

HLA-B27

A

95% w/Ankylosing spondylitis are HLA-B27+
8% of Caucasian population = HLA-B27+

80% w/Reactive Arth/Reiters are HLA-B27+

Enteropathic Arthritis w/sacroiliitis or spondylitis

Psoriatic Arthritis

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16
Q

HLA-CW6

A

Psoriatic Arthritis

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17
Q

HLA-B8

A

Sjogrens

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18
Q

HLA-DR3

A

Sjogrens

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19
Q

Anti-Ro

A

Sjogrens (90%) also RF (75%)

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20
Q

Lip Biopsy in Sjogrens

A

Periductal and perivascular CD4+ TH cells, B cells, plasma cells , fibrosis

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21
Q

Anti-La

A

Sjogrens (60-90%)

SLE (10-15%)

22
Q

MPO-ANCA

A

Anti-myeloperoxidase ANCA

=Microscopic PolyAngiitis
&
=Churg-Strauss Δ
- necrotising vasculitis
- asthma
- allergic rhinitis
- pulmonary infiltrates
- increased circulating eosinophils
- necrotizing granulomas (extrvascular)
23
Q

PR3-ANCA

A 
Anti-proteinase-3 ANCA
= Wegener’s Granulomatosis
- Upper airways (necrotising granulomas)
- Necrotising granulomatous vasculitis (small-medium vessels)
- Necrotising glomerulonephritis
24
Q

FcR-bearing cells (T-Cells – primarily Cytotoxic)

A

Accelerated Acute Rejection

25
Q

Anti-CD20

A

Treatment used in humoral acute rejection.
On CD4 staining.
Also seen = Polyconal Immunoglobulin, Plasmapharesis

26
Q

Minor histocompatibility antigens
Non-MHC encoded polymorphisms
Cytokine polymorphisms

A

Mechanism of GVHD which avoid “Matching”

Occasionally seen in autologous transplants die t re-emergence of autoreactive t-cells

27
Q

HLA-DRB1*04

A

Polymyalgia Rheumatica

28
Q

HLA-DRB1*01

A

Polymyalgia Rheumatica

29
Q

P-ANCA, purpura, lungs, kidneys, cvs, git, necrotizing glomerular nephritis, exogenous antigens from drugs , blood and infections.

A

Microscopic Polyangitis

30
Q

Triad:
Renal Disease
Chronic Sinusitis
Pneumonitis

ANCA+

A

Wegner’s Granulomatosis (Tx = Rapid Immunosup)

31
Q

Typically affects vessels of respiratory tract, strongly associated with asthma, eosinophilia and pulmonary infiltrates. May also have GI Sx (e.g. colitis, bleeding) +/- cardiac +/- peripheral neuropathy Sx’s.

P-ANCA+ and IgE

A

Churg-Straus Syndrome (Tx = Glucocortiocids +Support)

32
Q 
Anti-nuclear antibody (ANA)
Anti-dsDNA antibody
ENA antibodies
Anti-RBC antibody
Anti-cardiolipin & lupus anticoagulant
A

All auto-antibodies of Systemic Lupus Erythematous

33
Q

Anti-Sm (30%)
Anti-Ro (30%)
Anti-La

A

30% specific (except La) each for SLE

All are anti-ENA (extractable nuclear antigen).

34
Q

Jo-1

A

30% of Polymyosistitis

35
Q

RNP

A

100% Mixed Connective Tissue Disease

36
Q

Scl-70

A

A poor prognostic indicator for Scleroderma.

37
Q

IgA immune complexes deposited in mesangium.

A

IgA nephropathy.

38
Q

Anti-GBM antibody

A

Goodpastures

39
Q

Anti-CCP

A

Rheumatoid Arthritis

40
Q

DR4 and DR1

A

Rheumatoid Arthritis

41
Q

Principle Antibodies in Rheumatoid Arthritis

A 
Anti CCP (Specific 97%, sensitive 88%)
RF (Specific 65%, Sensitive 50-90%)
42
Q

Anti-PR3+

A

Granulomatosis with Polyangitis (GPA)

43
Q

Anti-ACHr (receptor)

A

Myasthenia Gravis

44
Q

Anti-MUSK (muscle specific tyrosine kinase)

A

Found in some anti-AchR negative MG

45
Q

IgA EMA

A 
Coeliac (90-100% sensitive and specific)
Dermatitis herpetiformis (50-70% sensitive, 90-100 specific)

False negative – gluten free diet

46
Q

Dx of Multiple Myeloma

A

Monoclonal expansion of paraprotein secreting plasma cells in bone marrow

IgG 60% of cases
IgA 20% of cases
Light chains alone 15-20% of cases

47
Q

NADPH oxidase (Phox)

A

Chronic Granulomatous Disease

48
Q

CD11a, 11b, 11c and CD18

A

Adhesion molecules (Neutrophil Function Disorder)

49
Q

Atophy

A 
Type 1 IgE mediated allergy (most common allergy)
10% population. 
- Asthma
- Hay Fever
- Eczema
- Foods
- Urticaria and angioedema 
- Anaphylaxis
50
Q

Type 2 Allergy

A

Autoantibody

51
Q

Type 4

A

Patch Test (Angry Back Syndrome)

52
Q

Graft Rejection Pathophysiology

A

APC-TCR = CD4 proliferation, release of IL2 and recruitment of Cytotoxic CD8+Tcells

immunopath (3 decks)

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