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PBD I > Immunopathology > Flashcards

Immunopathology Flashcards

1
Q

type I (immediate/anaphylactic) hypersensitivity

A

mediated by TH2 cell cytokines
IL-4: B cells class switch to IgE
IL-5: development and activation of eosinophils

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2
Q

type II (Ab-mediated) hypersensitivity

A

secreted IgG and IgM Abs directly injure cells

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3
Q

type III (immune complex mediated) hypersensitivity

A

IgG and IgM Abs bind Ags, Ab-Ag complexes deposit in tissues and induce inflammation

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4
Q

type IV (cell mediated) hypersensitivity

A

sensitized T-lymphocytes (TH1 and TH17 and CTLs)

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5
Q

vasoactive substances

A

histamine, PAF, neutral proteases (activate complement and kinins), leukotrienes C4 D4 E4, prostaglandin D2

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6
Q

smooth muscle contractors

A

histamine, PAF, leukotrienes C4 D4 E4, prostaglandins (D2)

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7
Q

cellular infiltration

A

cytokines, neutrophil and eosinophil chemotactic factors, leukotriene B4

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8
Q

hereditary angioedema

A

autosomal dominant C1 inhibitor deficiency, presents with asphyxia, nausea, vomiting, diarrhea post minor trauma or emotional stress

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9
Q

Type I diabetes

A

HLA DR3/4

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10
Q

autoimmunne hepatitis

A

HLA DR3

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11
Q

primary sjogren syndrome

A

HLA DR3

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12
Q

ankylosing spondylitis

A

HLA B27

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13
Q

postgonococcal arthritis

A

HLA B27

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14
Q

rheumatoid arthritis

A

HLA DR4, PTPN22 gene

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15
Q

IBD (Crohn’s disease)

A

NOD2

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16
Q

anti-centromer Ab

A

CREST syndrome

17
Q

anti-dsDNA, anti-Sm Abs, Ro/La

A

SLE

18
Q

Ag: DNA topoisomerase I
Ab: Scl-70

A

systemic sclerosis/scleroderma

19
Q

Ro and La Abs

A

Sjogren syndrome

20
Q

Jo-1 Ab

A

autoimmune myositis

21
Q

SLE presentation

A

malar/discoid rash, photosensitivity, arthritis, renal disorder, antinuclear Ab, Libman-Sachs endocarditis

22
Q

multiple myeloma/plasmocytoma amyloid protein

A

AL

23
Q

chronic inflammatory conditions amyloid protein

A

AA

24
Q

chronic renal failure amyloid protein

A

B2-microglobulin

25
Q

systemic senile amyloidosis amyloid protein

A

transthyretin

26
Q

Alzheimers amyloid protein

A

APP

27
Q

medullary carcinoma of thyroid

A

calcitonin

28
Q

T2 diabetes

A

islet amyloid peptide

PBD I (3 decks)

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