Immunopathology

Question 1

What is the HLA system?

Answer 1

• the property of having the same, or sufficiently similar, alleles of a complex of genes on chromosome 6

Question 2

What is the difference between MHC-I and MHC-II?

Answer 2

• MHC-I: present on all nucleated cells within the body

- MHC-II: binds to foreign antigens to present on APC

Question 3

What is graft-versus-host disease (GVHD)?

Answer 3

• Donated bone marrow or blood stem cells attack the recipient’s body

Question 4

What are the three steps in the pathogenesis of GVHD?

Answer 4

1. APC activation
2. Donor T cell activation
3. Cellular and Inflammatory response

Question 5

How are APC activated in GVHD?

Answer 5

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