Immunomodulators Flashcards
Define monoclonal antibodies, and describe in principle how they are made.
Made from multiple myeloma cells,
Discuss the use of monoclonal antibodies as anti-inflammatory agents.
You can target TNF for example
Chimeric Monoclonal antibodies
Fusion of mice and human antibodies
VL and VH domains, but human C domains;
Human Monoclonal Antibodies
Completely human antibodies
Humanized Monoclonal Antibodies
only the CDR’s of the V domains are from the mouse
Define NK cells and ADCC. Discuss the effect of Class I MHC expression levels on susceptibility of target cells to CTL and NK cells, respectively. Describe the mechanism for ADCC.
NK cells are lymphocytes that are larger than others, (arge granular lymphocyte)
No VDJ rearrangement, so not adaptive
Recognizes damaged or stressed cells
ALso as FC receptors for IgG bound to our cells
Describe how a monoclonal antibody against a T cell surface molecule could enhance the activity of a CTL.
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Discuss the use of modified (drugs, isotopes) monoclonal antibodies in tumor diagnosis or therapy.
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