Immunology Transition Flashcards
What are the clinical features of immunodeficiency?
SPUR
Serious infections
Persistant infections
Unusual infections
Recurrent infections
What conditions are associated with secondary immune deficiency?
Infection
treatment interventions
malignancy
biochemical and nutritional disorders
What is the most commmon genetic cause of primary immunodeficiency?
X linked SCID - Severe combined Immunodeficiency syndrome
What is affected in X linked SCID?
IL2 receptor
How does X linked sevre combined immunodeficiency present?
unwell by 3 months of age
Persistent diarrhoea
Failrue to thrive
Infections
What is a granuloma?
Organised collection of activated macrophages and lymphocytes
What is the most common antibody deficeiency?
Selectiv IgA deficiency
What are the common symptoms of antibody deficiencies?
reccurent bacterial infections
What is a type II hypersensitivity reaction?
Direct cell killing
What antibodies do type II hypersnesitivity reactions?
IgG
IgM
What are type III hypersnsitivity reactions?
Immune complex mediated
What are type IV hypersensitvity reactions?
Delayed type
What complement protein can act like a highlghter?
c3B
What complement protein is well good for punching holes in shit?
C5b and C(
What cells do vaccines work with?
They stimulate rare naive T Cells
Some of these then become effector t cells
a lot of those die, but some become memory T cells
