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CP: Immunology serology > Immunology serology > Flashcards

Immunology serology Flashcards

1
Q 
Genes for light and heavy chains are found on what chromosomes respectively? 
A. Chromosome 2, 4 and 6
B. Chromosome 2, 22 and 14
C. Chromosome 4, 6 and 14
D. Chromosome 4, 22 and 16
A

B.

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2
Q 
Which of the following IgG subtype cannot cross the placenta? 
A. IgG1
B. IgG2
C. IgG3
D. IgG4
A

B.

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3
Q 
Which of the following IgG subtype cannot activate the complement system?
A. IgG1
B. IgG2
C. IgG3
D. IgG4
A

D.

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4
Q 
Which of the following surface antigens points to a mature thymocyte? 
A. CD34+, TdT+
B. Surface CD3+
C. TdT (-), CD1 (-), CD3+
D. CD1 +, TdT+, CD5+
A

C.

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5
Q 
What is the normal ratio of CD4:CD8 count?
A. 2:1
B. 1:2
C. 4:1
D. 1:4
A

A.

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6
Q

Which of the following is true regarding natural killer cells?
A. They express TCR and Ig
B. They express CD3
C. They represent 10% of peripheral blood lymphocytes
D. They express CD16 and CD38

A

C.

Remarks: CD3 - mature T cells; TCR and Ig are not expressed in NK cells. NK cells express CD16, CD56 and CD57.

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7
Q 
Class II genes encoding HLA class II antigens are found in the following except. 
A. B cells
B. Macrophages
C. activated T-cells
D. Platelets
A

D.

Remarks: Class I - all nucleated cells and platelets (rbcs have minimal Class I).

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8
Q 
The chance of having an HLA-identical sibling with two siblings is how many percent? 
A. 25%
B. 45%
C. 60%
D. 75%
A 
B. 
Remarks: 
1 sibling - 25%
2 siblings - 45%
3 siblings - 60%
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9
Q 
Which of the following HLA subtype is protective of insulin-dependent diabetes mellitus?
A. HLA-DR2
B. HLA-DR3
C. HLA-DR4
D. HLA-B27
A

A.

Remarks: HLA-DR3 and 4 are associated with IDDM.

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10
Q 
The following autoimmune diseases are more common in women, except?
A. SLE
B. Primary biliary cirrhosis
C. Ankylosing spondylitis
D. Graves Disease
A

C.

Remarks: it is more common in men.

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11
Q 
This infection in particular is associated with the onset of ankylosing spondylitis?
A. Coxsakie B virus
B. Hepatitis B infection
C. Klebsiela pneumonia
D. Malaria
A

C.

Remarks: Coxsakie B is assoicated with IDDM and HBV with PAN.

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12
Q 
With a patient suspected with sarcoidosis, there is elevation of this laboratory finding and is extremely useful test in the diagnosis.
A. LDH
B. ACE
C. AST
D. ALT
A

B.

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13
Q 
Which serum autoantibody is highly specific granulomatosis polyangitis and is often used to monitor this disease? 
A. Myeloperoxidase
B. p-ANCA
C. Anti-mitochondrial antibodies
D. Anti-proteinase 3
A

D.

Remarks: Granulomatous polyangitis is Wegeners granulomatosis. c-ANCA is also called Anti-proteinase 3 (PR3).

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14
Q 
This serum autoantibody is highly specific and highly sensitive for Hashimoto disease.
A. Anti-endomysial 
B. Anti-GBM
C. Anti-microsomal
D. Anti-PM1
A

C.

Remarks: Anti-endyomysial is for celiac sprue and dermatitis herpetiformis.

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15
Q 
This disease is characterized by fulminant and often fatal immune response to Epstein-Barr virus (EBV) infection inducing a hemophagocytic syndrome. 
A. Wiskott-Aldrich syndrome
B. Duncan disease
C. Louis-Bar syndrome
D. Job syndrome
A

B

Remarks: Louis-Bar syndrome is also known as ataxia-telangiectasia.

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16
Q 
Chronic granulomatous disease are often associated with what blood group phenotype? 
A. McLeod 
B. Lutheran
C. Lewis
D. Bombay
A

A.

Remarks: McLeod - very weak expression of Kell antigens

17
Q 
This specific anti-mitochondrial antibody is associated with primary biliary cirrhosis. 
A. Anti-M1 
B. Anti-M2
C. Anti-M5
D. Anti-M7
A

B. - M2

18
Q 
The following drugs are associated with drug-induced lupus, except.
A. isoniazid
B. procainamide
C. hydralazine
D. methyldopa
A

D.
Remarks: Methyldopa (aldomet) associated with autoimmune hemolytic anemia (warm type).
HLA-DR4 associated with hydralazine
HLA-DR6 associated with procainamide

19
Q 
All are Immune complex mediated type of hypersensitivity, except. 
A. Henoch-Schonlein purpura 
B. Polyarteritis nodosa
C. Acute rheumatic fever
D. Post streptococcal glomerulonephritis
A

C.

Remarks: acute rheumatic fever - antibody cross reacts with myocardial antigen.

20
Q 
All are T-cell mediated type of hypersensitivity, except. 
A. Multiple sclerosis
B. Insulin-resistant diabetes
C. Type 1 DM
D. Inflammatory bowel disease
A

B.
Remarks: Insulin-resistant DM is type 2 because the target is the insulin receptor.
Take note: Type 2 - acute rheumatic fever; Type 3- post strep glomerulonephritis; Type 4 - rheumatic arthritis.

21
Q

The following statements regarding antithyroid antibodies are true, except.
A. Indirect immunofluorescence with anti-microsomal antibody highlight the follicular epithelium.
B. Indirect immuofluorescence with anti-thyroglobulin antibody highlight the colloid.
C. Hashimoto thyroiditis is positive for anti-microsomal, anti-thyroglobulin and long-acting thyroid stimulating (LATS) antibodies.
D. Graves disease is positive for LATS antibodies.

A

C.

Remarks: Hashimoto is positive for anti-microsomal and anti-thyroglobulin only and negative for LATS.

22
Q 
Autoimmune pancreatitis is associated with what particular IgG subtype? 
A. IgG1
B. IgG2
C. IgG3
D. IgG4
A

D. G4

23
Q 
Which of the following IgG subtype is the most predominant? 
A. IgG1
B. IgG2
C. IgG3
D. IgG4
A

A. G1

24
Q

True or false. Indirect Coombs Test can detect complement proteins?

A

False - because complement proteins are bound proteins and can only be detected on Direct Coombs Test.

25
Q 
Which of the following is indicative of primary and secondary Sjogren syndrome?
A. Anti-Ro
B. Anti-La
C. All of the above
D. None of the above
A

A. - Anti-Ro/ Anti-SSA

Remarks: Anti-La/SSB is for primary Sjogren syndrome only.

26
Q

Myasthenia gravis antibody testing shows positive for MuSK only. Which of the following is true of this subtype?
A. It is more common in women and ages <40 yo
B. It is more common in men and ages >40 yo
C. It is of seronegative type of MG
D. It is thymoma-associated

A

C.

27
Q

What is the most common disorder associated with Sjogren syndrome? (AP question)

A

Rheumatoid arthritis

28
Q

What particular malignancy is associated with a high risk of development in Sjogren syndrome? (AP question)

A

Marginal Zone lymphoma (B cell lymphoma)

29
Q

What is the most common complement deficiency?

A

C2

CP: Immunology serology (2 decks)

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