Immunology Qbanks

Question 1

Toll like receptors

Answer 1

Responsible for Lipid A of LPS endotoxin of gram - bacteria cell surface bind to CD14 of macrophages. Cause fever and hypotension seen in community acquired pneumonia

Question 2

The ESR is a measurement of the speed at which red cells settle to the bottom of a tube. This rate increases in the setting of inflammation largely due to increased levels of fibrinogen which causes red cells to stick together.

Answer 2

Acute phase reactants

ESR + C reactive protein is caused by cytokines

Question 3

CD4+ T-cells and natural killer cells are lymphocytes that can live for years. They do not decline as rapidly as neutrophils in patients on chemotherapy. What does?

Answer 3

Granulocytes, neutrophils

Question 4

T cells only recognize

Answer 4

peptides (aka polysaccharide capsules will not be detected)

Question 5

CD8 works on

Answer 5

viruses and tumor cells (but if the MHC complex is destroyed.. Natural Killer Cells will take care of it)

Question 6

TH1 can activate cytotoxic T cells by secreting

Answer 6

IL2 and it will kill tumor cells!

but if the MHC complex is destroyed in tumor cells. Natural Killer Cells will take care of it)

Question 7

The role of cytotoxic CD8+ T-cells is to recognize virally-infected cells and induce apoptosis. This takes away the cellular machinery that viruses need to replicate. Hepatitis B primarily infects \_\_\_\_\_\_\_\_\_.
These cells will present viral antigens on their surface in the context of MHC class 1, and bind CD8+ T-cells.

Answer 7

hepatocytes.

Question 8

T cell receptor gene rearrangement occurs in

Answer 8

Cortex of Thymus

Question 9

IFN gamma receptor deficiency causes…

Answer 9

severe dessiminated myocbacterial disease

need stem cell transplant

Question 10

Although EBV infects B-cells, atypical lymphocytes are _________. These cells increase in number to eliminate EBV-infected B-cells.

Answer 10

CD8+ (cytotoxic) T-cells

Question 11

malignant melanoma regression caused by

Answer 11

cytotoxic T cells (REMEMBER THEY WORK FOR CANCER ATTACKING!)

Question 12

IL 4

Answer 12

Th2 promote class switching to IgE,

Question 13

IL5

Answer 13

Th2 cells to promote class switching to IgA and eosinophils

Question 14

CD19 and CD20 on B cells

Answer 14

CD19 is expressed on the surface of follicular dendritic cells and B cells beginning from the pro-B phase but is not the target of EBV.

CD20 is expressed on the surface of all B cells beginning from the pro-B phase but is not the target of EBV.

Question 15

CD14

Answer 15

Lipid A of LPS binds to CD14/ macrophage marker also

Question 16

Degeorge vs. AIRE defiency

Answer 16

AIRE gene makes self antigens in medulla of thymus.

Candida infections, hypoparathyroidism too!, adrenal insufficiency

Degeorge causes no thymus, chromosome 22, pharyngeal arch 3 and 4 gone, no parathyroid, (tetany) and no great vessels and heart disease like VSD

Question 17

Intracytoplasmic/cellular eosinophilic inclusion bodies

Answer 17

Parkinson/Lewy Body Dimentia

Question 18

Streptococcus pyogenes, or group A strep, causes macrophages to produce _____ that causes fever

Answer 18

interleukin-1 (IL-1).

TH2 produces IL6 but that is more for parasites…