Immunology - Overview

Question 1

primary cells of the inflammatory reaction to be first found

Answer 1

neutrophils

Question 2

active naturally acquired

Answer 2

infection of host

Question 3

active artificially acquired

Answer 3

vaccine

Question 4

passive naturally acquired

Answer 4

maternal transfer

Question 5

passive artificiality acquired

Answer 5

Immunoglobulin transfer

Question 6

Sargramostim (Leukine)

Answer 6

dose-dependent increase in production of neutrophils and monocytes

Question 7

GM-CSF AE’s

Answer 7

fever, n/v/d, malaise, HA, chills, rash

Question 8

Filgrastim (Neupogen)

Pegfilgrastim (Neulasta)

Answer 8

affects primarily neutrophils

Question 9

G-CSF AE’s

Answer 9

bone pain, n/v, increased uric acid, hypersensitivity reactions

Question 10

Epoetin-alfa (Procrit)
Darbepoetin alfa (Arnesp)

Answer 10

erythroid progenitors to differentiate and mature into RBC

Question 11

ESAs AEs

Answer 11

hypertension, fever, n/v,

Question 12

Peginterferon Alfa-2a and 2b (Pegasys) (PegIntron)

Answer 12

inhibits viral replication

Question 13

What does the pegylated moiety add to interferon

Answer 13

reduces dosing frequency and adverse effects

improves PK and sustained viral response

Question 14

Interferon AE’s

Answer 14

bone pain, myalgia, fever, fatigue

Question 15

Intravenous Immunoglobulin

Answer 15

an IV blood product containing at least 90% pooled IgG

Gammagard

Question 16

Monoclonal Antibodies

Answer 16

“silver bullets”

immunoglobulin sequences that recognize a specific AG

Question 17

two classes of MoABs

Answer 17

unconjugated (naked)

immunoconjugates

Question 18

Limitations of MoABs

Answer 18

limited production
antigenic modulation
chronic impact - unknown long term effects
Hypersensitivity reactions

Question 19

Anti-TNF-a therapies

Answer 19

FUSION proteins of soluble TNF-a receptors (Etanercept)
Monoclonal Antibodies
modify the activity of TNF-a and reduce inflammation