Immunology of Endocrine Disease (finish) Flashcards

1
Q

Definition of autoimmune disease

A

A large group of clinical disorders which are characterised by tissue or organ damage through aberrant immunological mechanisms which are directed against autoantigens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

2 broad subtypes of autoimmune disease

A

Organ specific

Non-organ specific

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Examples of organ specific autoimmune disease

A

Thyroid Hashimotos, thyroiditis, thyroxitosis
Stomach - pernicious anaemia
Addisons disease
Juvenile diabetes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Examples of non organ specific autoimmune diseases

A

SLE
Scleroderma
RA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Autoimmune disease is a multifactorial interaction of what?

A
Genetic factors (susceptibility)
Environmental factors (aetiology)
Autoimmune mechanisms (pathogenesis)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Pathology of T1DM

A

Immune mediated B cell destruction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Pathology of T2DM

A

Insulin resistance/deficiency/secretory defect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Autoantigens known in graves disease

A

HLA-B8

DR3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly