Immunology of Endocrine Disease (finish) Flashcards
Definition of autoimmune disease
A large group of clinical disorders which are characterised by tissue or organ damage through aberrant immunological mechanisms which are directed against autoantigens
2 broad subtypes of autoimmune disease
Organ specific
Non-organ specific
Examples of organ specific autoimmune disease
Thyroid Hashimotos, thyroiditis, thyroxitosis
Stomach - pernicious anaemia
Addisons disease
Juvenile diabetes
Examples of non organ specific autoimmune diseases
SLE
Scleroderma
RA
Autoimmune disease is a multifactorial interaction of what?
Genetic factors (susceptibility) Environmental factors (aetiology) Autoimmune mechanisms (pathogenesis)
Pathology of T1DM
Immune mediated B cell destruction
Pathology of T2DM
Insulin resistance/deficiency/secretory defect
Autoantigens known in graves disease
HLA-B8
DR3