Immunology III: Innate Immunity & Inflammation 2 (Part 5 Time course and appearance) Flashcards
Acute inflammation questions!
Given a viral invader:
What PRRs could be activated in the tissue?
What cells are likely detecting the invader?
What signals could they send out – relate to each stage of inflammation:
Vasodilation
Increased vascular permeability
Emigration
Which cells are most likely to be recruited from the circulation?
Given a bacterial invader:
What are the major innate immune defences that can destroy an invader early on (before adaptive immunity)?
Molecules?
Cells and cellular activities?
Given a viral invader:
What PRRs could be activated in the tissue?
What cells are likely detecting the invader? Could still get neutrophils and macrophages, but aren’t good at viruses
NK cells are much better at viruses. Toll-like 3 and Rig-like, type 1 interferons
What signals could they send out – relate to each stage of inflammation:
Vasodilation
Increased vascular permeability- prostaglandins
Emigration
Which cells are most likely to be recruited from the circulation?
Given a bacterial invader:
What are the major innate immune defences that can destroy an invader early on (before adaptive immunity)? Macrophages, neutrophils, dendrites, mast cells,
Toll-like receptor 1 (gram negative)
Toll-like receptor 2 (gram positive)
Molecules? Macrophage secretes these after excitement. Cytokines: IL 1, IL 6, TNF alpha, Prostaglandins, PAF (Prost. Activating factor) nitric oxide. These are all asking for more help.
Cells and cellular activities after initiated: increased vascular activity (dilation) Complement components, SAA, CRP, C5a, C3a
t- cells, b-cells (ONLY if needed, but everything else is likely enough)
What are the outcomes of acute inflammation? CHART
