Immunology-IgA/CVI/specific(functional) Flashcards
IgA deficency
<7 mg/dL IgA but normal levels of IgG, IgE, IgM
Do pts w/ IgA deficency have norm response to vaccines
Yes
they are protected by vaccines
BUT STILL WANT TO AVOID LIVE VACCINES
What does IgA usually protect in normal pts
protects against infections of mucus membranes lining mouth, airway, GI system
Do IgA def patients have risk of get blood
Yes
Increased risk for anaphylactic rxn following exposure to blood infusions.
anti-IgA
needs wash RBCs or an IgA def donor
Are most people with IgA def asymptomatic
Yes
low IgA creates increase in IgM
Replacement of immunoglobulins is NOT recommended
How do symptomatic pts presents
recurrent sinopulmonary infections or GI infections
leads to bronchiolitis
IgA and celiac disease
IgA def can lead to a false negative for celiac disease
Common Variable Immunodeficency
hypogammaglobulinemia
immune system fails to protect against bacteria and viruses
BAFF cytokine receptor
What are presenting factors of CVI
-recurrent infections (sinopulmonary)
-enlarged lymphnodes (chest, neck
-parasitic GI infections
-severe fatigue
-G/I S/S
-increased risk for malignancy
-increased risk for autoimmune diseases
-Increased risk for infection from encapsulated organisms
What are encapsulated organisms
Staph A
H influenza
Stept pneumo
Moraxella
Psuedomonas in bronch
Can pts with CVID be protected w/ vaccines
NO
What if patient has bronchiectasis of unknown hx
Test for CVID
CVID on CT imaging
noncaseating, noninfectious granulomas found on liver, spleen, eyes, lymphoid tissue, and/or lungs
Labs of CVID
Immunglobulin levels
B-cell levels
CVID tx
No Cure
Corticosteroids
cyclosporins
cyclphosphamide
IVIG
