immunology i

Question 1

kostmann?

Answer 1

congenital neutropenia, (recurrent) infections 2 weeks post-natally

Question 2

side effect anti-TNF

Answer 2

reactivates latent TB

Question 3

defect/s haemopoetic stem cell differentiation causes?

Answer 3

reticular dysgenesis

Question 4

digeorge?

Answer 4

failed thymus development

Question 5

hypogammaglobulinaemia?

Answer 5

no mature B cells

Question 6

common variable immunodef.?

Answer 6

low IgG/A/E

Question 7

role mast cells in allergic response?

Answer 7

express Fc receptors, produce inflammatory mediators

Question 8

clinical effect histamine etc in lung?

Answer 8

bronchoconstriction, vasodilation, vasc. permeability, mucosal oedema, yellow sputum

Question 9

type II hypersensitivity mechanism?

Answer 9

complement pathway

Question 10

4 effects of complement activation?

Answer 10

direct killing via MAC, opsonisation via C3b, solubilisation immune complexes, chemotaxis

Question 11

type III hypersensitivity mechanism?

Answer 11

immune complexes

Question 12

type IV hypersensitivity mechanism?

Answer 12

T cells

Question 13

term for collection activated macrophages/ lymphocytes?

Answer 13

granuloma

Question 14

type hypersensitivity is acute cellular rejection?

Answer 14

IV

Question 15

time frame for chronic allograft failure?

Answer 15

> 30 days