Immunology Cases

Question 1

What is the new UK wide SCID newborn screening programme?

Answer 1

Taking dried blood to daignose early for cure

Question 2

What things would you want to know in a clinical evaluation?

Answer 2

History
SPUR infections (Severe, Persistant, Unusual, Recurrant)
End organ damage
Age/gender
Family history
Drug history

Question 3

What is involved in the differential diagnosis of hypogammaglobulinaemia?

Answer 3

Protein loss and low IgG
Hyper catabolism of Ig in sepsis
Drugs
Lymphoproliferative disorders/haem malignancy
Primary antibody deficiency
Rare genetic disorders

Question 4

Case - 26 years old lady: perennial sneezing, nasal itch, itchy eyes, much worse during summer. Oral tingling when she eats apples, plums and peaches. No asthma but wheezy in the summer. What tests would you use to diagnose this and what is the diagnosis?

Answer 4

Skin prick test or serum specific IgE testing done in the lab

Allergic perennial rhinoconjunctivitis and an oral allergy