Immunology And Disease Flashcards

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1
Q

Definition of infection

A

Transmissible disease often acquired by inhalation, ingestion or physical contact

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2
Q

Definition of endemic

A

Disease occurring frequently at a predictable rate, in a specific location and population

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3
Q

Definition of carrier

A

An infected person or organism showing no symptoms but able to infect others

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4
Q

Definition of disease reservoir

A

The long term host of a pathogen, always a potential source of disease outbreak

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5
Q

Definition of pandemic

A

An epidemic over a very wide area, crossing international boundaries, affecting a very large number of people

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6
Q

Definition of epidemic

A

The rapid spread of infectious disease to a large number of people in a short period of time

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7
Q

What is the virus lyric cylle

A
  • immediately reproduce using hosts metabolism to copy their own nucleic acid and synthesise new coat protein.
    Released by lysis of host cell or budding
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8
Q

What is virus lysogenic cycle

A
  • integrate nucleic acid into host cell genome
  • may remain for many generations
  • enter lytic cycle later
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9
Q

4 mechanisms which cells are pathogenic

A
  • cell lysis
  • toxins
  • cell transformation
  • immune suppression
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10
Q

Broad spectrum antibiotics

A

Kill a range of bacteria

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11
Q

Narrow spectrum bacteria

A

Only kill a specific type of bacteria

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12
Q

Bactericidal bacteria

A

Kill the bacteria

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13
Q

Bacteriostatic bacteria

A

Prevent cell division, do not cause death

Resume normal metabolism when antibiotic is removed

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14
Q

What is active immunity?

A

The body makes its own antibodies, stimulated by either infection or vaccination.

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15
Q

What is vaccination?

A

A weakened or killed pathogen, or toxin/ antigen derived from it, which stimulates the immune system to produce an immune response against it without causing infection.

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16
Q

What may vaccines contain?

A
  • antigens isolated from pathogen
  • weakened strains of a pathogen
  • inactive/ killed pathogen
  • inactivated toxin
17
Q

What is passive immunity?

A

The body receives antibodies produced by another individual

18
Q

How does passive immunity occur naturally?

A

From mother to foetus across the placenta or in breast milk

19
Q

How can passive immunity be used in a vaccination?

A

When rapid resistance is needed, there is no time for the active immune response to develop

20
Q

What factors affect the effectiveness of vaccines?

A
  • antigen should be highly immunogenic

- only one antigenic type of pathogen

21
Q

Why do influenza A vaccines have to be given annually?

A
  • undergoes genetic recombination and frequent mutation

- memory cells produced in first exposure may not be stimulated in subsequent exposure if virus has mutated

22
Q

What is herd immunity?

A

If enough people are vaccinated successfully against a contagious disease, there are fewer live pathogens in the population, meaning fewer people will become infected in the future

23
Q

When are vaccinations not advised?

A
  • immunocomprimised
  • taking chemotherapy
  • living with hiv
  • very old
  • very ill
24
Q

Why might people refuse vaccinations?

A
  • religious objections
  • preference for natural medicine
  • mistrust for pharmaceutical companies
  • safety fears