Immunology AC Flashcards
Function of the immune system
Protect the host (body) against environmental agents or organism. It is an organized series of actions in response to a pathological organism
Intention of the immune system
To destroy or neutralize the invader
The immune system identifies and destroys __________ and _________
Dead cells and malignant cells
Organs of the immune system
Bone marrow, thymus gland, spleen, and lymph system
Which organ is the cell production center?
Bone marrow
B and T cells are generated in the ________from_______
Bone marrow from stem cells
Where do B cells mature and differentiate?
Bone marrow
Where do T cells mature?
Thymus gland
What is WBC stand for?
White Blood Cells or Leukocytes
Which cells participate in natural and acquired response?
WBC or Leukocytes
What does the spleen do?
Filters the blood looking for foreign cells, stores different defense cells, stores RBC’s, and breaks down old RBC’s
What does the lymph system do?
Drains and filters fluids to detect and remove bacteria
Components of the lymph system
Lymph nodes and mucosal lymphatic system
What is also called an antibody generator?
An antigen
What is an antigen
A substance recognized as foreign or “no self” by immune system
What is an antigen capable of?
Capable of triggering an adaptive (specific) immune response
What are the 4 stages of the immune response?
I. Recognition stage, II. Proliferation stage, III. Response stage, and IV. Effector stage
What happens in the recognition stage?
Antigens are recognized by circulating lymphocytes and macrophages
What happens in the proliferation stage
The dormant lymphocytes proliferate and differentiate into cytotoxic (killer) T cells or B cells responsible for formation and release of antibodies
What happens in the response stage
The cytotoxic T cells and B cells perform cellular and hormonal functions respectively
What happens in the effector stage
Antigens are destroyed or neutralized through the action of antibodies, complement, macrophages, and cytotoxic T cells
How is an antibody also called
Immunoglobulin (a large PR)
Antibodies or immunoglobulins are formed in response to what?
In response to specific antigens by B lymphocytes (cells)
How do antibodies or immunoglobulins tag and/or inactivate antigens?
Phagocytosis, precipitation, neutralization, lysis, agglutination, opzonization.
The immune response is divided in 2 categories
Innate (natural) immunity and adaptive (acquired) immunity
Characteristics of innate(natural) immunity
1st line of defense after antigen exposure with an inflammatory response, non-specific (no memory), we are born with it➡️has genetic influence, ⬇️ tissue damage and work of the adaptive immune system, includes skin and mucosa barriers
Characteristics of adaptive (acquired) immunity:
Specific to an antigen (has memory), it is a systematic response, 2 types: passive and active.
What is passive adaptive (acquired) immunity?
Temporary immunity and produced by a source outside the body
Examples of passive adaptive (acquired) immunity?
Immune globulins (antitoxin, snake venom antitoxin, HBIG-Hepatitis B immunoglobulins) and maternal antibodies transferred via placenta or breastmilk.
Phagocytosis immune response primary involves _______and it is the ________ response to most invading organism
WBC and it is the initial response for most invading organism
Humoral response involves…
B-lymphocytes and production of Immunoglobulins
Types of immunoglobulins
IgG, IgA, IgM, IgE, IgD
Cell mediated response is initiated by ________
T-lymphocytes