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Year 5 Pathology Overview > Immunology > Flashcards

Immunology Flashcards

1
Q

Recall one vaccine that is not safe in HIV infection?

A

Yellow Fever

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2
Q

Recall 4 conditions for which human normal immunoglobulin is useful

A

ITP
Kawasaki
Guillan Barre
Measles

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3
Q

Recall 3 uses of IFN alpha

A 
ABC
IFN A for 
Hep B
Hep C
C ML
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4
Q

Recall 2 uses of IFN beta

A

Bechet’s

Relapsing MS

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5
Q

Recall a use of IFN gamma

A

Chronic Granulomatous disease

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6
Q

Recall two immune checkpoints that can inhibit CD8+ T cell activation

A

APC CD86-CTLA4 (T cell)

Tumour) PD-1 - PDL-1 (CD8+ T cell

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7
Q

What type of vaccine is pneumococcus?

A

Conjugate

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8
Q

Which receptor does ipilimumab bind to, and what is it used to treat?

A

CTLA4

Malignant melanoma

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9
Q

How do steroids affect phagocytes?

A

Decrease neutrophil trafficking –> transient increase in plasma level

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10
Q

Which cells do azothioprine mostly affect, and which patients should never have azothioprine?

A

AzoThioprine
T cells
Tpmt mutations
(Ts)

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11
Q

What is the MOA of mycophenalate?

A

Blocks de novo guanosine synthesis

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12
Q

What is the main risk of mycophenalate?

A

Reactivation of HSV or JCV (causing PML)

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13
Q

What is the MOA of cyclophosphamide?

A

Alkylate guanine

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14
Q

What is cyclophosphamide mostly used for?

A

Wegeners, SLE

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15
Q

What are the 2 main side effects of cyclophosphaide

A

Cystitis

Bladder cancer

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16
Q

What is the MOA of methotrexate

A

Anti-folate

17
Q

What is the main contraindication of methotrexate?

A

Pregnancy

18
Q

What is the indication for plasmapheresis?

A

Type II hypersensitivity

19
Q

What is the MOA of calcineurin inhibitors?

A

Stops expression of IL2 from T cells

20
Q

What are PDE4 inhibitors used for?

A

Psoriasis

21
Q

What is the Basiliximab MOA?

A

Basilisk is in HP2

Targets IL-2R

22
Q

What is the MOA and main indication of rituximab?

A

Anti-CD20

B cell lymphomas

23
Q

Write a card about

A

T cell and B cell rejection

24
Q

What is the pathology of acute T cell mediated transplant rejection?

A

Type IV hypersensitivity

25
Q

What is the pathology of acute antibody mediated transplant rejection?

A

Vasculitis ??

26
Q

Which MHC is most important when matching donors?

A

HLA-DR

27
Q

Which type of rejection can be treated with plasmapheresis?

A

Acute antibody-mediated

28
Q

Which type of transplant rejection leads to fibrosis?

A

Chronic

Year 5 Pathology Overview (4 decks)

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