Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

2MB Dermatology (My version) > Immunology > Flashcards

Immunology Flashcards

You may prefer our related Brainscape-certified flashcards:
Dermatology Board Prep flashcards
1
Q

Name 3 important structural proteins found in the keratin layer and epidermis of skin

A

Filaggrin
Involucrin
Keratin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the alternative name for the keratin layer of skin?

A

Stratum corneum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Keratinocytes produce antimicrobial peptides (AMP) that can directly kill pathogens. True/False?

A

True

Act like antibiotics (non-cell-mediated immunity)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Can keratinocytes produce cytokines and chemokines?

A

Yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Where are Langerhans cells located in the epidermis?

A

Prickle cell layer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Langerhans cells are the main skin immune cell. True/False?

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How do Langerhans cells aid the immune response?

A

Produce liquid antigen/microbial fragments and present them to T-cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What characterises Langerhans cells?

A

Birbeck granule

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Healthy skin contains a large number of T-cells. The epidermis mainly contains CD4 T-cells. True/False?

A

False

Epidermis mainly contains CD8 cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

CD4 Th_ cells are associated with psoriasis
CD4 Th_ cells are associated with atopic dermatitis
CD4 Th_ cells are associated with psoriasis + atopic dermatitis

A

CD4 Th1 cells are associated with psoriasis
CD4 Th2 cells are associated with atopic dermatitis
CD4 Th17 cells are associated with psoriasis + atopic dermatitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the function of TH1 cells?

A

Activate macrophages to destroy microorganisms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the function of TH2 cells?

A

Help B cells to make antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the function of dermal dendritic cells?

A

Antigen presenting

Cyto/chemo -kine secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the function of plasmacytoid dendritic cells?

A

Produce IFN-alpha

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

MHC I present exogenous antigen to CD8 cells. True/False?

A

False

They present endogenous antigen to CD8 cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

MHC II present exogenous antigen to CD4 cells. True/False?

A

True

17
Q

Psoraisis is triggered by environmental factors in genetically susceptible individuals. True/False?

A

True

18
Q

Psoraisis lesions can be restored to normal state following effective therapy, even though there is chronic inflammation. True/False?

A

True

19
Q

It is common for psoraisis plaques to become squamous cell carcinoma. True/False?

A

False

20
Q

In psoraisis, the keratinocytes are stressed. Activated T-cells produce cytokines and IL-17A. What is the significance/function of IL-17A?

A

Stimulates keratinocyte proliferation, AMP release and neutrophilic killing
Basically acts as a synapsis between skin and immune system

21
Q

People with atopic eczema always have dry skin. True/False?

A

True

22
Q

Gene mutations for which protein are associated with severe/early atopic eczema?

A

Fillagrin

23
Q

How does a broken down skin barrier cause eczema?

A

Exposed skin is sensitised to allergen and promotes colonisation by microorganisms

24
Q

Allergic type 1 hypersentivity reactions typically occurs within minutes up to hours. What are the principle skin reactions that occur?

A

Urticaria

Angioedema

25
Q

List step-up therapy for allergic reactions

A

Antihistamine
Prednisolone
Adrenaline

26
Q

Allergic contact dermatitis is an example of which hypersensitivity reaction?

A

Type IV

27
Q

What is the time period for type IV hypersensitivity reactions?

A

24-48hrs

2MB Dermatology (My version) (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions