Immunology

Question 1

In a patient who has a significantly high ANA titre, which autoantibody would you test for next?

Which CTD is this antibody associated with?

Answer 1

Anti-dsDNA

SLE

Question 2

Which connective tissue disease are Anti-Ro and Anti-La associated with?

Answer 2

Sjogren’s syndrome

Question 3

Which connective tissue disease is Anti-Jo1 ​associated with?

Answer 3

Dermato/Polymyositis

Question 4

Which connective tissue disease is Anti-centromere antibody ​associated with?

Answer 4

Limited systemic sclerosis

CREST symptoms

Complication: pulmonary hypertension

Question 5

Which connective tissue disease is Anti-Scl70 antibody ​associated with?

Answer 5

Diffuse systemic sclerosis

Complication: pulmonary fibrosis

Question 6

What are the CREST symptoms of limited systemic sclerosis?

Answer 6

Calcinosis

Raynaud’s phenomenon

Oesophageal dysmotility

Sclerodactyly

Telangectasia

Question 7

Which markers are used in the diagnosis of rheumatoid arthritis?

Answer 7

Inflammatory markers e.g CRP, PV

RF

Anti-CCP antibody

Question 8

Name three small vessel vasculitidies.

Answer 8

Microscopy polyangiitis

Granulomatosis with polyangiitis (formerly Wegener’s)

Eosinophilic granulomatosis with polyangiits (formely Churg-Strauss)

Question 9

Which autoantibodies are associated with

a) Microscopy polyangiitis
b) GWP
c) EGWP?

Answer 9

a) p-ANCA

b) c-ANCA

c) p-ANCA