Immunology Flashcards
Name 3 important structural proteins found in the keratin layer and epidermis of skin
Filaggrin Involucrin Keratin
What is the alternative name for the keratin layer of skin?
Stratum corneum
Keratinocytes produce antimicrobial peptides (AMP) that can directly kill pathogens. True/False?
True Act like antibiotics (non-cell-mediated immunity)
Can keratinocytes produce cytokines and chemokines?
Yes
Where are Langerhans cells located in the epidermis?
Prickle cell layer
Langerhans cells are the main skin immune cell. True/False?
True
How do Langerhans cells aid the immune response?
Produce liquid antigen/microbial fragments and present them to T-cells
What characterises Langerhans cells?
Birbeck granule
Healthy skin contains a large number of T-cells. The epidermis mainly contains CD4 T-cells. True/False?
False Epidermis mainly contains CD8 cells
CD4 Th_ cells are associated with psoriasis CD4 Th_ cells are associated with atopic dermatitis CD4 Th_ cells are associated with psoriasis + atopic dermatitis
CD4 Th1 cells are associated with psoriasis CD4 Th2 cells are associated with atopic dermatitis CD4 Th17 cells are associated with psoriasis + atopic dermatitis
What is the function of TH1 cells?
Activate macrophages to destroy microorganisms
What is the function of TH2 cells?
Help B cells to make antibodies
What is the function of dermal dendritic cells?
Antigen presenting Cyto/chemo -kine secretion
What is the function of plasmacytoid dendritic cells?
Produce IFN-alpha
MHC I present exogenous antigen to CD8 cells. True/False?
False They present endogenous antigen to CD8 cells