Immunology Flashcards
MHC Type matched with HLA loci associated with it
MHC I: HLA-A, HLA-B, HLA-C
(MHC I loci have 1 letter)
MHC II: HLA-DP, HLA-DQ, HLA-DR
(MHC II loci have 2 letters)
pg 96
HLA B27 disease associations
Psoriatic arthritis
Ankylosing Spondylitis
IBD-associated arthritis
Reactive arthritis
PAIR (aka seronegative arthropathies)
pg 96
HLA DQ2/DQ8 disease association
Celiac Disease
I ate (8) too (2) much gluten at Dairy Queen (DQ)
pg 96
HLA DR 2 Disease Association
Multiple Sclerosis
hay fever
SLE
Goodpasture syndrome
“Multiple hay pastures have dirt”
pg 96
HLA DR3 disease association
SLE
“2,3 S L E”
pg 96
HLA DR4 disease association
Rheumatoid arthritis, DM type I, Addison disease
There are 4 walls in a rheum (room)
pg 96
Roles of different cytokines
IL1-IL6
“Hot T-bone stEAK”
IL-1: fever (hot)
IL-2: stimulates T cells
IL-3: stimulates bone marrow
IL-4: stimulates IgE production
IL-5: stimulates IgA production
IL-6: stimulates aKute-phase protein production
pg 104
Role of IL-8
“Clean up on aisle 8”
Neutrophils are recruited by IL-8 to clear infections
pg 104
Role of TGF-beta and IL-10
TGF-beta and IL-10 both attenuate the immune response
pg 104
Inactivated and Killed Vaccines
Hint: mnemonic is RIP Always
Rabies, Influenza (injection), Polio (Salk), hepatitis A
pg 107
X-linked (Bruton) aggamaglobulinemia
Defect in which enzyme, what is clinical sequelae?
Defect in BTK (Bruton tyrosine kinase), leads to no B cell maturation
pg 112
Selective IgA deficiency
clinical presentation
Majority Asymptomatic. Can see Airway and GI infections. Autoimmune disease, Atopy, Anaphylaxis to IgA-containing products
pg 112
Autosomal Dominant hyper-IgE syndrome (Job syndrome)
clinical presentation
Hint: mnemonic is FATED
FATED:
coarse Facies
cold (noninflamed) staphylococcal Abscesses
retained primary Teeth
Increased IgE
Dermatologic problems (eczema)
pg 112
Ataxia-telangiectasia
Defect in what gene/clinical presentation
Defects in ATM gene
Clinical presentation: cerebellar defects (Ataxia, spider Angiomas, IgA deficiency)
pg 113
Wiskott-Aldrich Syndrome
Clinical Presentation
Hint: mnemonic is WATER
WATER
Wiskott-Aldrich: Thrombocytopenia, Eczema, Recurrent (pyogenic) infections.
pg 113
