Immunology

Question 1

What is the nemonic “SHiNE SKiS”?

Answer 1

Encapsulated bacteria removed by spleen:
Streptococcus pneumoniae
Haemophilus influenza B
Neisseria meningitidis
Escherichia coli
Salmonella spp
Klebsiella pneumoniae
Streptococci Group B

Question 2

Where do T cells mature? B cells?

Answer 2

T = Thymus
B = Bone Marrow

Question 3

What cell types are part of the innate immunity?

Answer 3

a. neutrophils (release ROS)
b. macs
c. monocytes
d. dendritic cells
e. NK cells
f. complement

Question 4

What cell types are part of the adaptive immunity?

Answer 4

a. T cells
b. B cells
c. circulating Abs

Question 5

What are toll-like receptors? Are they part of adaptive or innate immunity?

Answer 5

TLRs recognize things that are pathogen specific like LPS and ssDNA.

Innate.

Question 6

Does MHCI present endo or exo pathogens? To whom? MHCII?

Answer 6

MHCI: present endogenous pathogen (eg- viral) to CD8+ cytotoxic T cells.

MCHII: presents exogenous pathogens to CD4+ T helper cells.

Question 7

What happens in the thymus if a T cell attacks “self” cells?

Answer 7

The cell is apoptosed. This is negative selection.

Question 8

What do Th1 cells do?

Answer 8

They release cytokines which help B cells class swtich… IgM > IgG for example.

Question 9

What do Th2 cells do?

Answer 9

Important for allergies, IgE sticks to mast cells.

Th2 = Th(achoo!)