Immunology Flashcards
Lymph nodes medullary sinus vs medullary cords
Medullary cords: plasma cells
Medullary sinus: macrophages (munching up things as they pass along)
Beta-2 microglobulin vs. invariant chain?
Beta-2 microglobulin associated with MHC I and invariant chain associated with MHC II (removed from MHC II and replaced by antigen right before expressing on cell surface)
HLA-A3 association
Hemochromatosis
HLA-DQ2/DQ8 association
Celiac disease
HLA-DR2 association
Multiple sclerosis, SLE, goodpastures
HLA-DR3 association
DM1, SLE, graves, hashimotos
HLA-DR4 association
Rheumatoid arthritis (4 walls in a "rhem") DM1
HLA-DR5 association
Pernicious anemia, hashimotos
Complement C3b purpose
Most important for opsonization
Neutrophil chemotaxis agents
Complement C5a, IL-8 (clean up in IL-8), Leukotriene B4
IL-5 cytokine affect
Stimulates IgA production
Myeloperoxidase
Enzyme involved in the neutrophil formation of reactive oxygen species. Final step in creation of hypochlorite (HClO, bleach).
Give sputum it’s color (greenish)
EBV target
CD21 on B-cells. NTBCw/ CD20 on Bcells: target of rituximab.
CD56
Unique marker for natural killer cells
Serum sickness & arthus reaction are examples of…
Type III hypersensitivity rxn involving antigen-antibody complexes that fix complement leading to immune cell activation
Anticentromere antibodies
Limited scleroderma (CREST)
Anti-glutamic acid decarboxylase (GAD-65)
Diabetes type 1
Anti-Jo, anti-SRP, anti-Mi2
polymyositis, dermatomyositis
Anti- DNA topoisomerase I
aka anti-scl70
Systemic scleroderma
Patient receives blood products and quickly has an anaphylatic rxn. Looking back at old lab studies her IgA appeared low. Dx?
IgA deficiency (most common primary immunodeficiency). Patients have anaphylactic rxns to IgA found in blood products when they themselves are deficient in IgA Rx: epinephrine for anaphylaxis
Patient presents with difficulty walking, a bunch of spider angiomas, and low levels of IgA, IgG, IgE. Dx?
Ataxia-telangiectasia syndrome. Defective ATM gene: failure to repair DNA double strand breaks.
Also have elevated AFP
Infant presents with umbilical cord still attached >30days from birth. Also has been having multiple bacteria skin and mucosal infections. Dx? Defect?
Leukocyte adhesion deficiency type 1 caused by defective LFA-1 integrin (CD18). Phagocytes don’t migrate to appropriate places: no pus formation, high serum neutrophils, none in sites of infection
Complement deficiencies C5-C9 associated with…
Recurrent Neisseria infections and bacteremia. Inability to form MAC complex.
Contrast with early complement deficiencies (e.g. C3): recurrent infections w/ encapsulated bacteria
Mediators of acute vs chronic transplant rejection
Acute: CD8 mediated host cells respond to donor MHcs
Chronic (months-years): CD4 mediated host cells respond to host presentation of donor peptides “Yo, have you seen these guys hangin around?”
