Immunology Flashcards
IL-1
aka osteoclast activating factor
Macrophages:
- inc neutrophil and macrophage migration (recruitment)
- inc acute phase reactants, fever and shock
IL-2
T Cells:
- inc T cell activation and proliferation
- inc NK cell and macrophage activity
- inc B cell growth
IL-3
T cells
- inc hematopoiesis (supports growth and differentiation of bone marrow stem cells)
- functions like GM-CSF
IL-4
Th2 cells - inc Th2 cell differentiation - inc B cell growth - inc isotype switch to IgE and IgG for parasites (stationed below intestines)
IL-5
Th2 cells
- inc differentiation of eosinophils
- inc isotype switching to IgA
growth and differentation of eosinophils (IgA for bacteria digested in gut in Peyers patches)
IL-6
Macrophages
- inc T and B cell growth
- inc osteoclast activity
causes fever and acute phase proteins
IL-8
Macrophages and T cells
- inc neutrophil activation and chemotaxis
“clean up on aisle 8”
IL-10
Th2 cells (INHIBITOR)
- dec Th1 cell differentiation
- dec cell-mediation immunity and APC activity
- inc B cell function
IL-12
Macrophages
- inc Th1 cell differentiation
- inc **NK cell and CD8+ T cell activity
Follicle of LN
B cell localization
secondary follicle: pale central germinal centers
hyperplasia in Rheumatoid Arthritis
Paracortex of LN
T cells
not well developed in DiGeorge
hyperplasia in extreme cellular immune response (virus: EBV)
Axillary LN
Breast, upper limb
Celiac LN
Stomach, liver, spleen, pancreas, upper duodenum
Superior mesenteric LN
lower duodenum, jejunum, ileum, colon to splenic flexure
Inferior mesenteric LN
colon from splenic flexure to upper rectum
Internal Iliac LN
lower rectum to anal canal; bladder; vagina; prostate
Para-aortic LN
Testes, ovaries, kidneys, uterus
Superficial inguinal
Anal canal (below pectinate line)
Right Lymphatic Duct
right side of body above diaphragm
Thoracic Duct
drains into junction of left subclavian and internal jugular veins
Splenic Dysfunction
dec IgM = dec complement = dec C3b = inc susceptibility to encapsulated organisms