Immunology 2 Flashcards
What 4 types of infections can you get that are indicative of immunodeficiency?
S - serious infection
P - persistant infections
U - unsual infections
R - recurrent infections
What would serious infection indicate?
Unresponsive to oral antibiotics
What would persistent infections indicate?
Early structural damage
Chronic infections
What would unusual infections indicate?
Unusual organisms
Unsusal sites
what would recurrent infections indicate?
Two major or one major and one recurrent minor infections in one year.
What might be some others features that would suggest primary immune deficiency?
Weight loss or failure to thrive Severe skin rash (eczema) Chronic diarrhoea Mouth ulceration Unusual autoimmune disease Family history
What different types of immunodeficiencies can you get?
Primary - rare
Secondary - common, often subtle, often involves more than one component of immune system
What cells and proteins are in the innate immune system?
Cells - macrophages, neutrophils, mast cells, NK cells
Proteins - complement, acute phase proteins, cytokines
What are the functions of the innate immune system?
Rapid clearance of microorganisms
Stimulates the acquired immune response
Buys time while the acquired immune system is mobilized
What cells and proteins are in the acquired
Cells - B lymphocytes, T lymphocytes
Proteins - Antibody
What are the functions of phagocytes?
Initiation and amplification of the inflammatory response
Scavenging of cellular and infectious debris
Ingest and kill microorganisms
Produce inflammatory molecules which regulate other components of the immune system
Resolution and repair
In phagocyte deficiency describe what might occur if there is a defect Defects of phagocyte production, mobilisation and recruitment?
There will be a failure to produce neutrophils - failure of stem cells to differentiate along myeloid linage
There might be a specific failure of neutrophil maturation - Kostmann syndrome
