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Transplant > Immunology > Flashcards

Immunology Flashcards

1
Q

Which is the most important cell for phagocytosis?

A

leukocytes

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2
Q

What are the two types of phagocytes?

A

-circulating (granulocytes and monocytes)
-fixed (macrophages)

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3
Q

Which cytokine stimulates bone marrow to release PMNs?

A

IL3

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4
Q

What type of cells are PMNs?

A

-neutrophils
-eosinophils
-basophils
-mast cells

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5
Q

What cytokine is important for early development of B-cells?

A

IL7

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6
Q

What are activated B cells called?

A

plasma cells

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7
Q

Which type of immune cell requires MHC to recognize an antigen?

A

T cells

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8
Q

What cytokines are responsible for B cell activation?

A

IL4

-also: IL2, IL6, IL7

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9
Q

Which immunoglobulin is the first to appear?

A

IgM

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10
Q

Which immunoglobulin is the mucosal immune antibody?

A

IgA

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11
Q

Which immunoglobulin is responsible for mast cell mediated immunity?

A

IgE

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12
Q

Which coagulation factor is stimulated by the activation of the complement system?

A

factor XI

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13
Q

What part of the T-cell receptor is essential and found in all TCRs?

A

CD3

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14
Q

Which cytokine receptor is only expressed by activated T-cells?

A

IL2

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15
Q

What are two immunosuppresive medications that are IL2 inhibitors?

A

-cyclosporin
-FK506

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16
Q

What type of T-cells have a CD4 unit of the T-cell receptor?

A

T helper cells
Th1 and Th2

17
Q

What type of T-cells have a CD8 unit of their T-cell receptor?

A

T cytotoxic cells
Tc1 and Tc2

18
Q

What has to be present for CD8 to act on a target?

A

MHC 1

19
Q

What is the role of interferon-gamma?

A

increases the expression of MHC 1 (HLA 1) on the cells to be attacked by T cytotoxic cells

20
Q

Which cells are antigen presenting cells?

A

-B cells
-macrophages
-dendritic cells

21
Q

What cells are MHC 1 found on?

A

all nucleated cells

22
Q

What cells are MHC 2 found on?

A

-B-cells
-monocytes
-macrophages
-some activated T-cells

Transplant (2 decks)

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