Immunology Flashcards
Innate immune response
Intrinsic
Nonspecific
No memory
Limited diversity
Adaptive immune response
Inducible Specific Memory Extensive diversity Self vs non-self recognition Self-limiting
IL-7
Lymphoid progenitor cell
GM-CSF, IL-3
Myeloid progenitor cell
IL-5
Eosinophil progenitor cell
CD 14
Monocytes and macrophages
CD 19, 20, 21
B cell
CD 3, 4
TH cell
CD 3, 8
CTL cell
CD 16, 56
NK cells
Naive B cell antigen receptors
IgM and IgD
T cell antigen receptor
Alpha and beta chains
Idiotype
N-terminal pocket of heavy and light chains
Isotype
C-terminal domains
B cell signal transduction complex
Recognizes unprocessed antigens
Ig-alpha, Ig-beta, CD 19, CD 20
T cell signal transduction complex
Recognizes cell-bound peptide
CD 3
Heavy chain variable domains
VDJ segments
Light chain variable domains
VJ segments
Tdt enzyme
Inserts bases randomly at VDJ junctions and creates more variability
Marker for early stage ALL
Allergic exclusion
One chromosome of a homologous pair will be inactivated, ensuring that only one idiotype will be produced per cell
Omenn syndrome
AR, missense mutation in rag genes
Lack of B cells, marked decrease of T cells
Early onset, failure to thrive, red rash, diarrhea, and sever immunodeficiency
Sever combined immunodeficiency
AR, nonsense mutations in rag genes
Total lack of B and T cells
Total defects in humoral and cell-mediated immunity
