Immunology

Question 1

Innate immune response

Answer 1

Intrinsic
Nonspecific
No memory
Limited diversity

Question 2

Adaptive immune response

Answer 2

Inducible
Specific
Memory
Extensive diversity
Self vs non-self recognition
Self-limiting

Question 3

IL-7

Answer 3

Lymphoid progenitor cell

Question 4

GM-CSF, IL-3

Answer 4

Myeloid progenitor cell

Question 5

IL-5

Answer 5

Eosinophil progenitor cell

Question 6

CD 14

Answer 6

Monocytes and macrophages

Question 7

CD 19, 20, 21

Answer 7

B cell

Question 8

CD 3, 4

Answer 8

TH cell

Question 9

CD 3, 8

Answer 9

CTL cell

Question 10

CD 16, 56

Answer 10

NK cells

Question 11

Naive B cell antigen receptors

Answer 11

IgM and IgD

Question 12

T cell antigen receptor

Answer 12

Alpha and beta chains

Question 13

Idiotype

Answer 13

N-terminal pocket of heavy and light chains

Question 14

Isotype

Answer 14

C-terminal domains

Question 15

B cell signal transduction complex

Answer 15

Recognizes unprocessed antigens

Ig-alpha, Ig-beta, CD 19, CD 20

Question 16

T cell signal transduction complex

Answer 16

Recognizes cell-bound peptide

CD 3

Question 17

Heavy chain variable domains

Answer 17

VDJ segments

Question 18

Light chain variable domains

Answer 18

VJ segments

Question 19

Tdt enzyme

Answer 19

Inserts bases randomly at VDJ junctions and creates more variability
Marker for early stage ALL

Question 20

Allergic exclusion

Answer 20

One chromosome of a homologous pair will be inactivated, ensuring that only one idiotype will be produced per cell

Question 21

Omenn syndrome

Answer 21

AR, missense mutation in rag genes
Lack of B cells, marked decrease of T cells
Early onset, failure to thrive, red rash, diarrhea, and sever immunodeficiency

Question 22

Sever combined immunodeficiency

Answer 22

AR, nonsense mutations in rag genes
Total lack of B and T cells
Total defects in humoral and cell-mediated immunity