Immunology

Question 1

Peri-rectal abscesses are seen most commonly with?

Answer 1

Hyper Ig-M syndrome

Question 2

Components of natural immune system?

Answer 2

Neutrophils, monocytes, complement

It is the first line of defense, non specific, does not rely on T or B cells.

Question 3

Most common early complement deficiency

Answer 3

C2

Increased risk of pneumococcal infection

Question 4

Deficiency of late complement increases risk of?

Answer 4

Neisseria infection

Question 5

Only immunoglobulin produced by the fetus?

Answer 5

IgM

Question 6

Where is IgA present?

Answer 6

Most abundantly in respiratory and GI tracts. Human colostrum and breast milk

Question 7

When does the bone marrow become the exclusive site for B cell formation?

Answer 7

30 weeks gestation

Question 8

Types of immune mediated neutropenia?

Answer 8

alloimmune neutropenia (maternal antibodies to paternal and fetal neutrophils. omphalitis and skin infections are the most common infections, but serious and life-threatening infections, including meningitis, may also occur)
neonatal passive autoimmune
autoimmune neutropenia of infancy

Question 9

How do you diagnose immune mediated neutropenia?

Answer 9

presence of circulating antineutrophil antibodies (positive granulocyte agglutination test)

Question 10

What is Kostmann’s syndrome?

Answer 10

Autosomal recessive
Maturational arrest of marrow myeloid precursors
Hypocellular bone marrow
Persistent and severe neutropenia with an ANC less than 200/μL.
Responds to GCSF