Immunology 10: Immune Deviation

Question 1

Induction of different classes of immunity is often ____. 2 questions this raises?

Answer 1

exclusive
→ i.e. occur under different conditions
→ raises questions: is class of immunity induced of significance to the host? What ensures exclusivity of induction of different classes?

Question 2

Is class of immunity induced of significance to the host?

Answer 2

YES
→ the class of immunity induced following infection of Mycobacterium leprae (leprosy) is crucial to course of disease -- cell-mediated is best able to contain it but antibody responses best able to neutralize toxins
→ induction of exclusive cell-mediated response results in limited disease but induction of humoral or mixed (cell-mediated and humoral) response results in chronic or fatal course: illustrates importance of class of immunity induced to consequences of an infection

Question 3

Induction of different classes of immunity not only is exclusive, but can prevent an attempt to induce an ____.

Answer 3

Opposing class
→ induction of antibody to an antigen prevents attempts to induce cell-mediated immunity via delayed-type hypersensitivity (DTH) to this antigen

Question 4

Humoral immune deviation

Answer 4

immune response to an antigen is locked into a humeral mode

→ prevents induction of cell-mediated response

Question 5

cell-mediated immune deviation

Answer 5

immune response to an antigen is locked into cell-mediated mode
→ prevents induction of antibodies

Question 6

What’s responsible for cell-mediated and humoral immune deviation?

Answer 6

→ generating spleen T cells: made when one kind of immunity is induced and they act to inhibit induction of opposing class

Question 7

ex of the T cells

Answer 7

→ in mice unresponsive for induction of DTH, after induction of antibody to an antigen, contain in spleen T cells molecules preventing induction of DTH to the antigen
→ in mice unresponsive to the induction of antibody, after immunization resulting in induction of DTH to antigen, contain in spleen T cells molecules preventing antibody response