immunology 1 - intro to the immune system Flashcards

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1
Q

what are the three main functions of the immune system?

A
  1. eliminate danger.
  2. without harming our own body in the process.
  3. remember the threat to respond more efficiently next time.
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2
Q

what is a pathogen?

A

a micro-organism which causes disease to its host.

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3
Q

what are commensals?

A

non-harmful bacteria that live in the bodies of humans & animals.

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4
Q

when eliminating threats, what is the infection usually caused by?

A

a pathogen.

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5
Q

what are the 4 main types of infectious micro-organisms?

A

bacteria, viruses, fungi and parasites.

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6
Q

what can commensals do?

A

they can produce molecules that benefit us and protect us from pathogens.

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7
Q

where can good bacteria (commensals) appear?

A

on mucosal surfaces, i.e., our gut & respiratory tract.

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8
Q

as well as infection, what else can immune cells defend against?

A

cancer cells.

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9
Q

what is a cancer cell?

A

a normal body cell which has accidentally acquired DNA mutations that make it go wrong.

(aka a self-cell that has gone bad)

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10
Q

what is immune recognition?

A

the ability of the immune system to distinguish self cells from non-self cells.

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11
Q

what causes autoimmune disease?

A

this happens when immune responses go wrong and attack the normal body cells.

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12
Q

what does immune effector function mean?

A

the ability to deal with infection and eliminate it without causing harm to the body in the process.

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13
Q

what happens the first time we get an infection?

A

we get symptoms of feeling ill, it will take time for the immune system to recognise, respond & fight off the pathogen.

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14
Q

what happens if the threat comes back again?

A

the immune system will respond faster, so it will kill the threat before we have any symptoms.

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15
Q

what is immune memory?

A

the ability for the immune system to remember antigens from pathogens & mount an immune response of greater magnitude.

also: with faster kinetics upon re-encounter of the same antigens.

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16
Q

what are the two arms of the innate system?

A

innate and adaptive immunity.

17
Q

what is the innate immune system?

A

a mixture of cells & barriers that quickly act to slow down/limit microbial invasion and disease causing processes.

18
Q

what are the two functions of the innate immune system?

A
  1. rapidly respond to slow down any pathogenic threats.

2. recruit adaptive immune cells.

19
Q

what is the adaptive immune system?

A

an immune response mediated by T & B lymphocytes, which is highly specific to the pathogen that induced it, and eliminates disease causing processes alongside the innate immune system.

this system is a more specific second line of defence.

20
Q

what are the functions of the adaptive immune system?

A
  1. mount a highly specific defence against pathogens.

2. remember the threat in case its encountered again.

21
Q

what is the adaptive immune system made up of?

A

made up of cells (T and B lymphocytes) and the antibodies produced by B lymphocytes.

22
Q

what is one main difference between innate & adaptive immune responses?

A

their anatomical location.

23
Q

where are immune cells made and what are they made from?

A

all immune cells are made in bone marrow, from pluripotent haematopoietic stem cells.

24
Q

where will you find innate immune cells?

A

in peripheral tissues.

25
Q

where will you find adaptive immune cells?

A

in central lymphoid tissues, the spleen and lymph nodes.

26
Q

where do b lymphocytes mature?

A

in bone marrow.

27
Q

where do b lymphocytes go, whilst they wait to be activated?

A

the spleen and lymph nodes.

28
Q

where do t lymphocytes mature?

A

in the thymus.

29
Q

where do t lymphocytes go, whilst they wait to be activated?

A

the spleen and lymph nodes.

30
Q

the respiratory tract is an example of what type of tissue?

A

peripheral tissue

31
Q

what type of tissues are lymph nodes?

A

central lymphoid tissues.

32
Q

what type of tissue are lymph nodes?

A

central lymphoid tissues.

33
Q

what are haematopoietic precursor cells?

A

stem cells which are capable of differentiating into red (oxygen carrying) and white (immune) blood cells.