Immunological Flashcards
What is a primary immunodeficiency?
a group of more than 300 rare, chronic disorders in which part of the bodies immune system is missing or functions improperly.
What are the signs of a primary immune deficiency?
- increased susceptibility to infections
- more frequent infections
- longer lasting infections
- opportunistic infections
what is an opportunistic infection?
an infection a person with a healthy immune system likely wouldn’t get
other symptoms of opportunistic infection?
- affects natural immune system
- cannot initiate -inflammatory response
- bacterial, fungal, viral infections
- recurring abscesses, bronchitis and sinusitits.
what type of cells cannot reach the vascular system with a PI?
neutrophils unable to reach site of infection, and remain in the vascular system
What is HIV?
human immune deficiency virus
What type of infection is HIV classified as?
a chronic infection, treated as outpatient
what is AIDS?
autoimmune deficiency syndrome
what type of infection is AIDS classified as?
Acute, maybe requiring hospitalization
what body fluids can HIV-1 be transmitted through?
blood seminal fluid vaginal secretions amniotic fluid breastmilk
how soon after exposure to AIDS/HIV should antivirals be started?
within 72 hours of exposure
what are stages of HIV based on?
stages based on clinical condition and CD4+T cell count
how soon are antibodies produced after infection?
antibodies are produced usually within 3-12 weeks after infection
What tests detect antibodies?
Blood test, EIA
if EIA is positive; Western blot assay confirms seropositivity
what company uses saliva to perform an EIA?
OraSure
what do you do when you are exposed to HIV/AIDS?
wash area with soap and water, flush splashes to the nose, mouth, or skin with water
report incident to your supervisor
immediately seek medical treatment
manifestations of HIV?
can include any system
infection, malignancy of body tissue
what are the respiratory issues with HIV and AIDS?
pneumocystitis pneumonia
Tuberculosis
oral candidiasis
what is the most common respiratory condition with HIV and AIDS?
pneumocystis pneumonia
80% without prophylactic treatment
how does pneumocystis pneumonia present?
initially vague symptoms, progress to significant pulmonary impairment and respiratory failure
how is pneumocystis pneumonia diagnosed?
sputum, bronchial-alveolar lavage, transbronch biopsy
tuberculosis with HIV/AIDS?
often latent disease, 10% risk developing active
how common is oral candidiasis with HIV and AIDS?
occurs in almost all patients
symptoms of GI problems with HIV/AIDS?
- loss appetite, N/V, oral and esophageal candidiasis, chronic diarrhea
- related to direct affect of virus or tx protocol
- weight loss, progressive tissue wasting
oncologic s/s r/t HIV and AIDS?
kaposi’s sarcoma
lymphoma
invasive cervical cancer
what is kaposi’s sarcoma?
- endothelial layer blood and lymphatic vessels
- localized cutaneous lesions to disseminated multi organ
- prognosis depends on extent of tumor, other HIV infections, CD4+ count