Immunoglobulins and cytokines Flashcards
IgG
most common immunoglobulin
enhances phagocytosis
fixes complement and foetal care
IgA
found in breast milk
provides localised protection on mucous membranes
it is the most commonly produced Ig
IgM
1st Ig made in response to infection
fixes complement
doesn’t pass to foetus
IgD
not much is known
involved in activating B cells
IgE
type 1 hypersensitivity
binds to Fc on mast cells and basophils
provides immunity to parasites
what is the role of a cytokine?
have a specific effect in communication and interaction between cells
includes interferon, interleukin and growth factors
IL1
macrophages
role in acute inflammation and fever
IL2
T helper 1 cell
growth and differentiation of T cell response
IL3
activated T cells
T cell proliferation
activates mature neutrophils and macrophages
IL4
T helper 2 cells
Differentiation and proliferation of B cells
IL5
TH2 cell
stimulates production of eosinophils
IL6
macrophages and TH2
differentiation of B cells
IL8
macrophages
neutrophil chemotaxis
IL10
TH2 cell
anti-inflammatory
inhibits TH1 cytokines
IL12
dendritic, macrophage, B-cells
activates NK cells
differentiates T cells into TH1 cells
