Immunoglobulin

Question 1

Immunogen

Answer 1

substances that when injected into the body cause an immune response

Question 2

Antibody

Answer 2

these are proteins that recognizes and binds to an antigen with very high specificity.

Question 3

Antigens

Answer 3

they are antibody receptors.

Question 4

valence

Answer 4

the amount of binding sites on a cell

Question 5

haptens

Answer 5

they are proteins structures that cannot elicit immune responses on their own, but can elicit immune response when bound to a carrier protein.

Question 6

weight of light and heavy chains

Answer 6

23KDA

50-70KDA

Question 7

what is immunoglobulin linked with

Answer 7

disulfide bonds

Question 8

number of amino acids in each heavy and light chain

Answer 8

110AA

Question 9

Functions of Ig

Answer 9

Antibody function

Effector function

Question 10

Ig Fragments include

Answer 10

Fc: easily crystallized, to perform effector functions
Fab: this part is important in providing antigen binding site for antibody binding

Question 11

Parts of Ig

Answer 11

hinge region
domain
heavy and light chains
intrasulfide bonds

Question 12

classes of Ig

Answer 12

IgA
IgD 
IgM 
IgE
IgG

Question 13

IgG

Answer 13

it is a monomer 7s
mainly found in extracellular and serum.
good opsonins
only Ig to cross the placenta

Question 14

IgM

Answer 14

pentamer 19s
can exist as a monomer
first Ig to be produced by the fetus
it can be an indication of recent infections

Question 15

IgA

Answer 15

monomer(11s), can exist as a dimer
2nd most abundant in serum
used to form mucosal barrier
binds to PMNs and lymphocytes.

Question 16

IgE

Answer 16

mainly monomer
no complement binding
involved in allergic reaction
IgE binds to Fc to cause immune response against parasites