Immunodeficiency - Secondary

Question 1

What is secondary immunodeficiency?

Answer 1

Caused by external factors: drugs, nutrition, virus, burns

Question 2

How to corticosteroids affect immunodeficiency?

Answer 2

Change leukocyte circulation - decreased lymphocyte number
Repeated dose - decreased antibodies
Decreased monocyte - return to normal 24 hours, increased neutrophil release - mature neutrophil from bone marrow

Question 3

How does cancer tx cause immunodeficiency -radiotherapy/.

Answer 3

Break DNA strand - increase apoptosis
Agents target cancer cells but also affect bone marrow and lymphoid tissue - reduce immune cell proliferation, differentiation and function

Question 4

How can chemotherapy cause immunodeficiency?- Cyclophosphamide

Answer 4

Drug activated inside body - cross link DNA

Affect lymphocytes- loss Ab production

Question 5

What immunosuppressant is used in organ transplant?

Answer 5

Cyclosporin
Affect T cell (IL-2 production)
Side effect: fungus beauveria Nivea

Question 6

Other use cyclosporin?

Answer 6

Psoriasis, dermatitis, autoimmune urticaria