Immunodeficiency

Question 1

is primary or secondary immune deficiency more common?

Answer 1

secondary

Question 2

what do you see elevated eosinophils for

Answer 2

allergies

parasites

Question 3

what do mast cells cause?

Answer 3

allergic reactions (lead to swelling/ anaphylaxis)

Question 4

what are the 2 types of lymphocytes?

Answer 4

B and T cells

Question 5

what can cause secondary immune deficiency?

Answer 5

bacterial or viral infection
malignancy, malnutrition
HIV, immunosuppresive therapy
splenectomy
nephrotic syndrome

Question 6

what do you do for a sepsis evaluation?

Answer 6

Blood culture, Urine culture, LP

Question 7

if your ANC is low what does it indicate?

Answer 7

strong correlation with survive and mobility

Question 8

Kids with _ or more ear infections within 1 year is a warning sign for primary immunodeficiency

Answer 8

eight

Question 9

how are many primary immunodeficiencies inherited

Answer 9

X linked

AR

Question 10

what is SPUR

Answer 10

Severe
Prolonged
Unusual
Recurrent infections

Question 11

when is a B cell defect usually seen?

Answer 11

after 6 months when maternal antibodies lost

Question 12

what is the most common immune deficiency

Answer 12

b cells

Question 13

what will a child with B cell defect show up with?

Answer 13

Persistent upper RTI (ear, sinus, pulm)

Question 14

what immunoglobulin has the slowest synthesis

Answer 14

IgA

Question 15

if a child presents with opportunitic infections what do they probably have a defect in?

Answer 15

T cells

Question 16

will a child with a B cell or T cell problem have failure to thrive?

Answer 16

T cell problem

Question 17

Profound lack of T-cell numbers or function and B-cell dysfunction resulting from absence of B cells from the gene defect itself or secondary to lack of T-cell function

Answer 17

SCID

Question 18

absence of pus or delayed loss of umbilical cord (>2 weeks) would indicate what?

Answer 18

neutrophil disorder

Question 19

Function in ordered integrated fashion to defend against infection and produce inflammation

Answer 19

complement

Question 20

test for complement defect

Answer 20

CH50

Question 21

presents with Recurrent bacterial infections
SLE-like illness
Recurrent meningococcal infections
glomerulonephritis

Answer 21

complement defects

Question 22

where do you start with testing for immunodeficiencies

Answer 22

H and P
CBC and Diff
quantitative immunoglobulins levels
specific antibody responses
IgG sub class analysis

Question 23

examples of secondary immunodeficiency

Answer 23

HIV
DM
sickle cell
malnutrition
zinc deficiency
nephrotic syndrome

Question 24

why is nephrotic a secondary immunodeficiency

Answer 24

Losing proteins (IgGs are proteins)