Immunodeficiency Flashcards
is primary or secondary immune deficiency more common?
secondary
what do you see elevated eosinophils for
allergies
parasites
what do mast cells cause?
allergic reactions (lead to swelling/ anaphylaxis)
what are the 2 types of lymphocytes?
B and T cells
what can cause secondary immune deficiency?
bacterial or viral infection malignancy, malnutrition HIV, immunosuppresive therapy splenectomy nephrotic syndrome
what do you do for a sepsis evaluation?
Blood culture, Urine culture, LP
if your ANC is low what does it indicate?
strong correlation with survive and mobility
Kids with _ or more ear infections within 1 year is a warning sign for primary immunodeficiency
eight
how are many primary immunodeficiencies inherited
X linked
AR
what is SPUR
Severe
Prolonged
Unusual
Recurrent infections
when is a B cell defect usually seen?
after 6 months when maternal antibodies lost
what is the most common immune deficiency
b cells
what will a child with B cell defect show up with?
Persistent upper RTI (ear, sinus, pulm)
what immunoglobulin has the slowest synthesis
IgA
if a child presents with opportunitic infections what do they probably have a defect in?
T cells
will a child with a B cell or T cell problem have failure to thrive?
T cell problem
Profound lack of T-cell numbers or function and B-cell dysfunction resulting from absence of B cells from the gene defect itself or secondary to lack of T-cell function
SCID
absence of pus or delayed loss of umbilical cord (>2 weeks) would indicate what?
neutrophil disorder
Function in ordered integrated fashion to defend against infection and produce inflammation
complement
test for complement defect
CH50
presents with Recurrent bacterial infections
SLE-like illness
Recurrent meningococcal infections
glomerulonephritis
complement defects
where do you start with testing for immunodeficiencies
H and P CBC and Diff quantitative immunoglobulins levels specific antibody responses IgG sub class analysis
examples of secondary immunodeficiency
HIV DM sickle cell malnutrition zinc deficiency nephrotic syndrome
why is nephrotic a secondary immunodeficiency
Losing proteins (IgGs are proteins)
