Immuno Set 7

Question 1

A patient presents with a Streptococcal throat infection. This is the sixth bacterial infection the patient has had within the past six months. You are beginning to suspect the patient has a deficiency in humoral immunity. Which of the following cell types is most likely decreased in this patient?

a. CD8+cells
b. CD14+cells
c. CD19+ cells
d. CD25+cells
e. CD56+cells

Answer 1

c. CD19+ cells

Question 2

A clinical trial is designing a monoclonal antibody to mitigate an infectious disease process of an extracellular pathogen. Which isotype of antibody should they choose to use in their design?

a. IgA
b. IgD
c. IgE
d. IgG
e. IgM

Answer 2

d. IgG

Question 3

A patient’s repetitive infections is attributed a defect in a protein necessary for initial B cell signaling and activation. The defect is most likely contained in which molecule?

a. Igα/Igβ
b. IgM
c. CD16
d. CD20
e. CD56

Answer 3

a. Igα/Igβ

Question 4

A 56-year-old female with a past medical history pertinent for chronic Hepatitis C infection presents with decreasing kidney function. A biopsy demonstrates deposition of immune complexes (ICs) in the kidney vasculature leading to immune-mediated damage. These immune complexes are composed of antigen bound to:

a. BCRs
b. dendriticcells
c. HLA Class II
d. Immunoglobulins
e. TCRs

Answer 4

d. Immunoglobulins

Question 5

You are counseling a new mother on how to care for her baby during different developmental stages. One of the items you want to go with her is the waning of maternal immune protection as the baby ages from birth over the first six months of life. The receptor responsible for the translocation of antibody across the placental endothelium and establishment of maternal immune protection for the developing fetus and newborn is:

a. FcγRIIIB(CD32)
b. FcRn
c. FcεRII (CD23)
d. FcαRI (CD89)
e. FcγRIIIA/B(CD16a/b)

Answer 5

b. FcRn

Question 6

A child presents with repetitive viral infections. He has a defect in granzyme production. The effector function of which cell types would be affected by this defect?

a. CD4+ T cells/Macrophages
b. CD4+ T cells/NK cells
c. CD8+ T cells/CD4+ T cells
d. CD8+ T cells/Macrophages
e. CD8+ T cells/NK cells

Answer 6

e. CD8+ T cells/NK cells

Question 7

A patient has difficulty clearing viral infections. Absolute count of CD8+ T cells in peripheral blood is normal. A defect is found in ligand expression on the surface of CD8+ T cells that accounts for the delay in resolution of viral infections. What ligand is most likely defective?

a. CD28
b. CD40L
c. FasL (CD95L)
d. IL-2R(CD25)
e. MHC/HLAClassII

Answer 7

c. FasL (CD95L)

Question 8

A 43-year-old patient presents with an acerbation of her asthma. Which of the following cell types is producing the cytokine responsible for generating the mediator of her asthma, a Type I hypersensitivity response?

a. Th1
b. Th17
c. Th2
d. Tregs

Answer 8

c. Th2

Question 9

A patient presents with a history of several persistent viral infections since birth. Laboratory testing reveals a defect in the initial pathway of T cell intracellular signaling. The molecule most likely containing the defect is:

a. TCR
b. ζchain(Zetachain)
c. IL-2R (CD25)
d. CD40L
e. LFA-1

Answer 9

b. ζchain(Zetachain)

Question 10

Chest imaging reveals two granulomas in the lower left lung of a patient who presented with cough and night sweats. Based on imaging and presenting symptoms, you diagnose them with an infection caused by Mycobacterium Tuberculosis, an obligate intracellular bacteria. Which of the following cell types would be the most helpful in resolving the patient’s infection?

a. Th1
b. Th17
c. Th2
d. Treg

Answer 10

a. Th1