Immuno HemeOnc

Question 1

SSA/Ro antibodies

Answer 1

congenital heart block

Question 2

antibodies to GM1 ganglioside

Answer 2

Guillain-Barre Syndrome

Question 3

oligoclonal IgG bands in CSF

Answer 3

multiple sclerosis

Question 4

anti-desmoglein antibodies

Answer 4

DM type 1

Question 5

eosinophil infiltration of epidermis

Answer 5

bullous pemphigoid

Question 6

anti-intrinsic factor antibodies

Answer 6

pernicious anemia

Question 7

antibodies to type 4 collagen

Answer 7

Goodpasture Syndrome

Question 8

thymoma on CT scan

Answer 8

myasthenia gravis

Question 9

elevated T3 and T4

Answer 9

Graves disease

Question 10

RF negative, uric acid positive blood work

Answer 10

psoriasis

Question 11

Autoimmune diseases that demonstrate a strong linkage to the class I MHC antigen HLA-B27 include…

Answer 11

reactive arthritis (Reiter's syndrome)
psoriasis
Crohn's disease
ankylosing spondylitis
ulcerative colitis

Question 12

rx for multiple sclerosis

Answer 12

interferon beta
dimethyl fumarate
natalizumab
glatiramer

Question 13

rx for pernicious anemia

Answer 13

cobalamin

Question 14

rx for rheumatoid arthritis

Answer 14

adalimumab

Question 15

rx for myasthenia gravis

Answer 15

pyridostigmine

Question 16

rx for thyrotoxicosis

Answer 16

radioactive iodine

Question 17

rx for type 1 DM

Answer 17

insulin

Question 18

rx for Hashimoto thyroiditis

Answer 18

levothyroxine

Question 19

A 12 yo girl presents with mucocutaneous candidiasis, hypoparathyroidism, and alopecia

Answer 19

autoimmune polyendocrine syndrome-1

Question 20

A 42 yo female presents with ataxia, swollen tongue, and megaloblastic anemia

Answer 20

pernicious anemia

Question 21

32 yo female presents with ptosis, limited adduction of the left eye, and weakness that resolves with rest

Answer 21

myasthenia gravis

Question 22

46 yo female presents with goiter, bradycardia, and cold intolerance

Answer 22

Hashimoto’s thyroiditis

Question 23

65 yo male presents with morning stiffness, symmetric finger deformities, and bony nodules over both wrists

Answer 23

rheumatoid arthritis

Question 24

21 yo female presents with asymmetrical joint pain, malar rash, and oral ulcers

Answer 24

systemic lupus erythematous

Question 25

8 yo male presents with nocturia, increased appetite, and RUQ GI pain

Answer 25

DM type 1

Question 26

29 yo female presents with darkened skin pigmentation, dizziness upon getting out of bed in the morning, and missed menstrual periods

Answer 26

Addison’s Disease

Question 27

58 yo male presents with fluid-filled blisters that were preceded by an itchy rash on both arms

Answer 27

bullous pemphigoid

Question 28

26 yo male presents with ascending paralysis and patellar tendon hyporeflexia two weeks after resolution of severe gastroenteritis

Answer 28

Guillain-Barre syndrome

Question 29

Tolerance to self antigens can be induced by…

Answer 29

T cell interaction with host cells that lack the B7 co-stimulator
receptor editing in immature B cells
maturation of self-reactive CD4+, CD25+, FOXP3+ T cells in the thymus
negative selection of double positive T cells in the thymic medulla